• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Nutritional Biochemistry >Caveolae: a regulatory platform for nutritional modulation of inflammatory diseases.
【24h】

Caveolae: a regulatory platform for nutritional modulation of inflammatory diseases.

机译：小窝：用于调节炎症性疾病的调控平台。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dietary intervention strategies have proven to be an effective means of decreasing several risk factors associated with the development of atherosclerosis. Endothelial cell dysfunction influences vascular inflammation and is involved in promoting the earliest stages of lesion formation. Caveolae are lipid raft microdomains abundant within the plasma membrane of endothelial cells and are responsible for modulating receptor-mediated signal transduction, thus influencing endothelial activation. Caveolae have been implicated in the regulation of enzymes associated with several key signaling pathways capable of determining intracellular redox status. Diet and plasma-derived nutrients may modulate an inflammatory outcome by interacting with and altering caveolae-associated cellular signaling. For example, omega-3 fatty acids and several polyphenolics have been shown to improve endothelial cell function by decreasing the formation of ROS and increasing NO bioavailability, events associated with altered caveolae composition. Thus, nutritional modulation of caveolae-mediated signaling events may provide an opportunity to ameliorate inflammatory signaling pathways capable of promoting the formation of vascular diseases, including atherosclerosis
机译：饮食干预策略已被证明是减少与动脉粥样硬化发展相关的几种危险因素的有效手段。内皮细胞功能障碍影响血管炎症，并参与促进病变形成的最早阶段。小窝是内皮细胞质膜中丰富的脂质筏微区，负责调节受体介导的信号转导，从而影响内皮的活化。小窝蛋白已经参与了与几种能够确定细胞内氧化还原状态的关键信号通路相关的酶的调节。饮食和血浆来源的营养物质可通过与小窝相关的细胞信号传导相互作用并改变其而调节炎症结果。例如，已证明omega-3脂肪酸和几种多酚可通过减少ROS的形成和增加NO的生物利用度来改善内皮细胞的功能，这与海绵体组成的改变有关。因此，对小窝介导的信号转导事件的营养调节可能为改善能够促进包括动脉粥样硬化在内的血管疾病形成的炎性信号通路提供机会。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号