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首页> 外文期刊>The Journal of Nutritional Biochemistry >Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life.
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Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life.

机译：通过在幼年期喂养 cis -9， trans -11共轭亚油酸来增强大鼠的抗体合成。

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摘要

Previous studies have demonstrated that the intake of a 1% conjugated linoleic acid (CLA) diet in an 80:20 mixture of cis-9,trans-11 and trans-10,cis-12 exerts age-specific effects on the immune system: immunoglobulin enhancement and proliferative down-modulation in neonatal and adult rats, respectively. The present study evaluates the influence of the same diet on antibody synthesis of early infant Wistar rats during suckling and/or after weaning. Dietary supplementation was performed during suckling and early infancy (4 weeks), only during suckling (3 weeks), or only in early infancy (1 week). CLA content in plasma and serum immunoglobulin (Ig) G, IgM and IgA concentration were determined. Proliferation, cytokines and Ig production were evaluated on isolated splenocytes. Cis-9,trans-11- and trans-10,cis-12-CLA isomers were detected in the plasma of all CLA-supplemented animals, and the highest content was quantified in those rats supplemented over the longest period. These rats also exhibited higher concentrations of serum IgG, IgM and IgA. Moreover, splenocytes from CLA-supplemented rats showed the highest IgM and IgG synthesis and interleukin (IL)-6 production, whereas their proliferative ability was lower. In summary, in infant rats, we observed both the enhance antibody synthesis previously reported in neonates, and the reduced lymphoproliferation previously reported in adults.
机译：先前的研究表明，在顺式9，反11和反式10，顺12的80:20混合物中摄入1％的共轭亚油酸（CLA）饮食会对免疫系统产生特定年龄的影响：免疫球蛋白增强和新生大鼠和成年大鼠的增殖性下调。本研究评估了相同的饮食对早期婴儿Wistar大鼠在哺乳期间和/或断奶后抗体合成的影响。在哺乳和婴儿早期（4周），仅在哺乳期间（3周）或仅在婴儿早期（1周）进行膳食补充。测定血浆中的CLA含量以及血清免疫球蛋白（Ig）G，IgM和IgA的浓度。在分离的脾细胞上评估增殖，细胞因子和Ig产生。在所有补充了CLA的动物的血浆中均检测到了顺式9，反式11和反式10，顺式12-CLA异构体，并且在最长的补充时间中定量了最高含量。这些大鼠还表现出较高浓度的血清IgG，IgM和IgA。此外，来自补充了CLA的大鼠的脾细胞显示出最高的IgM和IgG合成以及白介素（IL）-6产生，而它们的增殖能力却较低。总之，在婴儿大鼠中，我们既观察到了先前在新生儿中报道的增强的抗体合成，又观察到了先前在成年中报道的降低的淋巴细胞增殖。

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