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首页> 外文期刊>The Journal of Nutritional Biochemistry >Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer - preventive actions of dietary factors.
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Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer - preventive actions of dietary factors.

机译：乳腺上皮和基质的双向信号传递：对乳腺癌的影响-饮食因素的预防作用。

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摘要

The mammary gland is composed of two major cellular compartments: a highly dynamic epithelium that undergoes cycles of proliferation, differentiation and apoptosis in response to local and endocrine signals and the underlying stroma comprised of fibroblasts, endothelial cells and adipocytes, which collectively form the mammary fat pad. Breast cancer originates from subversions of normal growth regulatory pathways in mammary epithelial cells due to genetic mutations and epigenetic modifications in tumor suppressors, oncogenes and DNA repair genes. Diet is considered a highly modifiable determinant of breast cancer risk; thus, considerable efforts are focused on understanding how certain dietary factors may promote resistance of mammary epithelial cells to growth dysregulation. The recent indications that stromal cells contribute to the maintenance of the mammary epithelial "niche" and the increasing appreciation for adipose tissue as an endocrine organ with a complex secretome have led to the novel paradigm that the mammary stromal compartment is itself a relevant target of bioactive dietary factors. In this review, we address the potential influence of dietary factors on mammary epithelial-stromal bidirectional signaling to provide mechanistic insights into how dietary factors may promote early mammary epithelial differentiation to decrease adult breast cancer risk. All rights reserved, Elsevier.
机译：乳腺由两个主要的细胞区室组成：高度动态的上皮细胞，响应局部和内分泌信号而经历增殖，分化和凋亡循环，下层基质由成纤维细胞，内皮细胞和脂肪细胞组成，共同形成乳腺脂肪垫。乳腺癌起源于乳腺上皮细胞中正常生长调节途径的破坏，这归因于肿瘤抑制因子，致癌基因和DNA修复基因的遗传突变和表观遗传修饰。饮食被认为是乳腺癌风险的高度可改变的决定因素。因此，大量的精力集中在理解某些饮食因素如何促进乳腺上皮细胞对生长失调的抵抗力上。最近的迹象表明，基质细胞有助于维持乳腺上皮“小生境”，并且对脂肪组织作为具有复杂分泌组的内分泌器官的认识日益增加，这导致了一种新颖的范例，即乳腺基质室本身就是生物活性的相关靶标。饮食因素。在这篇综述中，我们探讨了饮食因素对乳腺上皮-间质双向信号传导的潜在影响，以提供有关饮食因素如何促进早期乳腺上皮分化以降低成年乳腺癌风险的机械见解。保留所有权利，Elsevier。

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