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首页> 外文期刊>The Journal of Nutritional Biochemistry >Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155.
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Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155.

机译：槲皮素及其代谢产物异鼠李素和槲皮素-3-葡萄糖醛酸对炎症基因表达的影响：miR-155的作用。

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摘要

In the present study the effect of quercetin and its major metabolites quercetin-3-glucuronide (Q3G) and isorhamnetin on inflammatory gene expression was determined in murine RAW264.7 macrophages stimulated with lipopolysaccharide. Quercetin and isorhamnetin but not Q3G significantly decreased mRNA and protein levels of tumor necrosis factor alpha. Furthermore a significant decrease in mRNA levels of interleukin 1 beta, interleukin 6, macrophage inflammatory protein 1 alpha and inducible nitric oxide synthase was evident in response to the quercetin treatment. However Q3G did not affect inflammatory gene expression. Anti-inflammatory properties of quercetin and isorhamnetin were accompanied by an increase in heme oxygenase 1 protein levels, a downstream target of the transcription factor Nrf2, known to antagonize chronic inflammation. Furthermore, proinflammatory microRNA-155 was down-regulated by quercetin and isorhamnetin but not by Q3G. Finally, anti-inflammatory properties of quercetin were confirmed in vivo in mice fed quercetin-enriched diets (0.1 mg quercetin/g diet) over 6 weeks.
机译：在本研究中，在用脂多糖刺激的小鼠RAW264.7巨噬细胞中，测定了槲皮素及其主要代谢物槲皮素-3-葡糖醛酸苷（Q3G）和异鼠李素对炎性基因表达的影响。槲皮素和异鼠李素，但Q3G却不明显降低肿瘤坏死因子α的mRNA和蛋白水平。此外，响应槲皮素治疗，白细胞介素1β，白介素6，巨噬细胞炎性蛋白1α和诱导型一氧化氮合酶的mRNA水平显着下降。但是，Q3G不会影响炎症基因的表达。槲皮素和异鼠李素的抗炎特性伴随着血红素加氧酶1蛋白水平的提高，血红素加氧酶1蛋白是转录因子Nrf2的下游靶标，已知可拮抗慢性炎症。此外，槲皮素和异鼠李素下调了促炎性microRNA-155，但Q3G却没有。最后，在6周内用富含槲皮素的饮食（0.1毫克槲皮素/克饮食）喂养的小鼠体内证实了槲皮素的抗炎特性。

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