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首页> 外文期刊>The Journal of Nutritional Biochemistry >Effects of weight loss on erythrocyte membrane composition and fluidity in overweight and moderately obese women.
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Effects of weight loss on erythrocyte membrane composition and fluidity in overweight and moderately obese women.

机译：体重减轻对超重和中度肥胖妇女的红细胞膜成分和流动性的影响。

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摘要

A previous study showed chemical and physical impairment of the erythrocyte membrane of overweight and moderately obese women. The present study investigated the effects of a low-calorie diet (800 kcal/day deficit for 8 weeks) on erythrocyte membrane properties in 70 overweight and moderately obese (body mass index, 25-33 kg/m2) normotensive, nondiabetic women. At the end of dietary intervention, 24.3% of women dropped out, 45.7% lost less than 5% of their initial weight (Group I) and only 30% of patients lost at least 5% of their initial body weight (Group II). Group I showed no significant changes in erythrocyte membrane composition and function. The erythrocyte membranes of Group II showed significant reductions in malondialdehyde, lipofuscin, cholesterol, sphingomyelin, palmitic acid and nervonic acid and an increase in di-homo- gamma-linolenic acid, arachidonic acid and membrane fluidity. Moreover, Group II showed an improvement in total cholesterol, low-density lipoprotein cholesterol, glycemia and insulin resistance. These changes in erythrocyte membrane composition could reflect a virtuous cycle resulting from the reduction in insulin resistance associated with increased membrane fluidity that, in turn, results in a sequence of metabolic events that concur to further improve membrane fluidity.
机译：先前的研究表明，超重和中度肥胖妇女的红细胞膜发生化学和物理损伤。本研究调查了低热量饮食（800 kcal /天的赤字，持续8周）对70例超重和中度肥胖（体重指数为25-33 kg / m 2 ）血压正常的非糖尿病女性。在饮食干预结束时，有24.3％的女性辍学，其中45.7％的女性体重减轻了不到其初始体重的5％（I组），只有30％的女性体重减轻了至少其初始体重的5％（II组）。第一组显示红细胞膜组成和功能无明显变化。第二组的红细胞膜显示丙二醛，脂褐素，胆固醇，鞘磷脂，棕榈酸和神经酸显着减少，而二同-亚麻酸，花生四烯酸和膜流动性增加。此外，第二组的总胆固醇，低密度脂蛋白胆固醇，血糖和胰岛素抵抗均得到改善。红细胞膜组成的这些变化可反映出与膜流动性增加相关的胰岛素抵抗降低所导致的良性循环，进而导致一系列代谢事件，从而进一步改善了膜流动性。

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