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首页> 外文期刊>The Journal of Nutritional Biochemistry >Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect.
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Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect.

机译：补充n-3脂肪酸缺乏饮食的母鼠鱼油可防止母脑区域二十二碳六烯酸水平下降，并具有产后抗焦虑作用。

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摘要

Docosahexaenoic acid (DHA) and arachidonic acid (AA) are the major polyunsaturated fatty acids (PUFA) in the neuronal membrane. Most DHA and AA accumulation in the brain occurs during the perinatal period via placenta and milk. This study examined whether maternal brain levels of DHA and AA are depleted during pregnancy and lactation due to meeting the high demand of the developing nervous system in the offspring and evaluated the effects of the reproductive cycle on serotonin metabolism and of fish oil (FO) on postpartum anxiety. Pregnant rats were fed during pregnancy and lactation with a sunflower oil-based n-3 PUFA-deficient diet without or with FO supplementation, which provided 0.37% of the energy source as n-3 PUFA, and the age-matched virgin rats were fed the same diets for 41 days. In both sets of postpartum rats, decreased DHA levels compared to those in virgin females were seen in the hypothalamus, hippocampus, frontal cortex, cerebellum, olfactory bulb and retina, while AA depletion was seen only in the hypothalamus, hippocampus and frontal cortex. Serotonin levels were decreased and turnover increased in the brainstem and frontal cortex in postpartum rats compared to virgin rats. FO supplementation during pregnancy and lactation prevented the decrease in maternal brain regional DHA levels, inhibited monoamine oxidase-A activity in the brainstem and decreased anxiety-like behavior. We propose that the reproductive cycle depletes maternal brain DHA levels and modulates maternal brain serotonin metabolism to cause postpartum anxiety and suggest that FO supplementation may be beneficial for postpartum anxiety in women on an n-3 PUFA-deficient diet
机译：二十二碳六烯酸（DHA）和花生四烯酸（AA）是神经元膜中的主要多不饱和脂肪酸（PUFA）。大脑中大多数DHA和AA积累是在围产期通过胎盘和牛奶发生的。这项研究检查了孕妇的DHA和AA水平是否由于满足后代神经系统发育的高需求而在妊娠和哺乳期被耗尽，并评估了生殖周期对血清素代谢和鱼油（FO）的影响。产后焦虑症。在妊娠和哺乳期间，给怀孕的大鼠喂饲不加或不添加FO的葵花籽油型n-3 PUFA缺乏饮食，这为n-3 PUFA提供了0.37％的能量来源，并喂养了年龄相匹配的处女大鼠同样的饮食41天。在两组产后大鼠中，在下丘脑，海马，额叶皮层，小脑，嗅球和视网膜中均观察到DHA水平低于雌性雌性，而仅在下丘脑，海马和额叶皮质中观察到AA耗竭。与原始大鼠相比，产后大鼠的血清素水平降低，脑干和额叶皮层的周转率增加。孕期和哺乳期补充FO可以防止孕产妇大脑区域DHA水平降低，抑制脑干中的单胺氧化酶A活性并减少焦虑样行为。我们建议生殖周期消耗母体脑DHA水平并调节母体脑5-羟色胺代谢以引起产后焦虑，并建议在n-3 PUFA缺乏饮食的女性中补充FO可能有益于产后焦虑

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