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首页> 外文期刊>The Journal of Nutritional Biochemistry >Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life.
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Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life.

机译：在大脑发育过程中暴露于母体n-3脂肪酸缺乏的饮食中，会引起雄性后代雄性后代的应激，抑郁和焦虑行为指数对下丘脑-垂体-肾上腺轴的过度反应。

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摘要

Brain docosahexaenoic acid (DHA, 22:6n-3) accumulates rapidly during brain development and is essential for normal neurological function. The aim of this study was to evaluate whether brain development was the critical period in which DHA deficiency leads to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress later in life. Rats were exposed to an n-3 fatty acid-deficient diet or the same diet supplemented with fish oil as an n-3 fatty acid-adequate diet either throughout the preweaning period from embryo to weaning at 3 weeks old or during the postweaning period from 3 to 10 weeks old. Exposure to the n-3 fatty acid-deficient diet during the preweaning period resulted, at weaning, in a significant decrease in hypothalamic DHA levels and a reduced male offspring body weight. DHA deficiency during the preweaning period significantly increased and prolonged restraint stress-induced changes in colonic temperature and serum corticosterone levels, caused a significant increase in GABAA antagonist-induced heart rate changes and enhanced depressive-like behavior in the forced swimming test and anxiety-like behavior in the plus-maze test in later life. These effects were not seen in male rats fed the n-3 fatty acid-deficient diet during the postweaning period. These results suggest that brain development is the critical period in which DHA deficiency leads to excessive HPA responses to stress and elevated behavioral indices of depression and anxiety in adulthood. We propose that these effects of hypothalamic DHA deficiency during brain development may involve a GABAA receptor-mediated mechanism. All rights reserved, Elsevier.
机译：脑二十二碳六烯酸（DHA，22：6n-3）在脑发育过程中迅速积累，对于正常的神经功能至关重要。这项研究的目的是评估大脑发育是否是DHA缺乏导致生命后期应激反应导致下丘脑-垂体-肾上腺（HPA）轴失调的关键时期。在从胚胎到断奶的整个断奶前期（三周大）或断奶后（从断奶到断奶）的整个过程中，大鼠均接受n-3脂肪酸缺乏饮食或与鱼油补充的相同n-3脂肪酸饮食。 3至10周大。断奶前在断奶期间暴露于n-3脂肪酸缺乏饮食会导致下丘脑DHA水平显着下降和雄性后代体重下降。断奶前DHA缺乏显着增加并延长了束缚应激诱导的结肠温度和血清皮质酮水平的变化，导致GABA A 拮抗剂引起的心率变化显着增加，并增强了抑郁样行为在以后的生活中，在迷宫测试中进行强迫游泳测试和类似焦虑的行为。在断奶后喂食n-3脂肪酸缺乏饮食的雄性大鼠中未观察到这些作用。这些结果表明，大脑发育是关键时期，其中DHA缺乏会导致HPA对压力过度反应以及成年期抑郁和焦虑行为指数升高。我们认为这些在大脑发育过程中下丘脑DHA缺乏的影响可能涉及GABA A 受体介导的机制。保留所有权利，Elsevier。

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