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首页> 外文期刊>The Journal of Nutritional Biochemistry >The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.
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The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.

机译：柑橘类黄酮橙皮素抑制去卵巢无胸腺小鼠中表达芳香化酶的MCF-7肿瘤的生长。

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摘要

Aromatase is responsible for the rate-determining reaction in estrogen synthesis and is a prime target for treating estrogen-receptor-positive breast cancer. Previous in vitro study has demonstrated that apigenin (APG), naringenin (NGN) and hesperetin (HSP) are three of the most potent natural aromatase inhibitors. Because the enzyme inhibition could potentially block breast cancer development, we employed an established postmenopausal breast cancer model to examine the chemopreventive effect of these flavonoids in vivo. Athymic mice were ovariectomized and transplanted with aromatase-overexpressing MCF-7 cells. Dietary administration of HSP at 1000 ppm and 5000 ppm significantly deterred the xenograft growth, while a null effect was observed in mice treated with APG or NGN. Further study illustrated that plasma estrogen in HSP-treated mice was reduced. Messenger RNA expression of the estrogen-responsive gene pS2 was also decreased in the tumors of mice treated with 1000 and 5000 ppm HSP. On the other hand, western analysis indicated that cyclin D1, CDK4 and Bcl-x(L) were reduced in the tumors. This study suggested that HSP could be a potential chemopreventive agent against breast carcinogenesis through aromatase inhibition
机译：芳香酶负责雌激素合成中的速率决定性反应，并且是治疗雌激素受体阳性乳腺癌的主要靶标。之前的体外研究表明，芹菜素（APG），柚皮素（NGN）和橙皮素（HSP）是最有效的三种天然芳香酶抑制剂。由于酶抑制作用可能会阻止乳腺癌的发展，因此我们采用了已建立的绝经后乳腺癌模型来研究这些类黄酮在体内的化学预防作用。将无胸腺小鼠切除卵巢，并用过表达芳香化酶的MCF-7细胞进行移植。饮食中以1000 ppm和5000 ppm的HSP饮食可显着阻止异种移植物的生长，而在用APG或NGN处理的小鼠中则观察到无效作用。进一步的研究表明，经HSP处理的小鼠血浆雌激素水平降低。在用1000和5000 ppm HSP处理的小鼠的肿瘤中，雌激素反应基因pS2的Messenger RNA表达也降低了。另一方面，western分析表明，肿瘤中细胞周期蛋白D1，CDK4和Bcl-x（L）减少。这项研究表明，HSP可能是通过抑制芳香化酶来预防乳腺癌的潜在化学预防剂。

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