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首页> 外文期刊>The Journal of Nutritional Biochemistry >Association of MAOA and COMT gene polymorphisms with palatable food intake in children.
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Association of MAOA and COMT gene polymorphisms with palatable food intake in children.

机译：MAOA 和 COMT 基因多态性与儿童可口食物摄入的关联。

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Several studies have implicated dopamine (DA) in appetite regulation. The enzymes catechol-o-methyltransferase (COMT) and monoamine oxidase A (MAOA) control DA availability and their genes have well-characterized functional variants. In this study, we examined three polymorphisms in these genes, T941G and MAOAu-VNTR in the MAOA gene and Val158Met in the COMT gene, to investigate how heritable variations in enzymes that determine DA levels might influence food intake and nutritional status. This investigation was a cross-sectional examination of 354 Brazilian children of three to four years old. Polymorphisms were analyzed by PCR-based methods. Means of dietary and anthropometric data were compared among genotypes by one-way analyses of variance or Kruskal Wallis tests. The MAOAu-VNTR and COMT Val158Met polymorphisms were associated with the amount of palatable food intake in boys. Presence of the MAOAu-VNTR long allele was associated with higher intake of lipid-dense foods (LDF) when compared with the short allele (P=.009); the amount of sugar-dense foods (SDF) intake was also higher in males carriers of the MAOAu-VNTR long allele than in carriers of the short allele (P=.034). In the girls' sample, MAOAu-VNTR polymorphism was not associated with food intake and nutritional status. Carriers of the COMT Val158Met Val allele presented higher intake of LDF when compared with Met/Met homozygotes (P=.008). This study provides the first indication that genetic variants of enzymes that control DA availability might be involved in determination of the amount of palatable food intake in children
机译：多项研究表明多巴胺（DA）参与了食欲调节。儿茶酚-o-甲基转移酶（COMT）和单胺氧化酶A（MAOA）可以控制DA的利用率，其基因具有功能明确的功能变异。在这项研究中，我们检查了这些基因的三个多态性，即MAOA基因中的T941G和MAOAu-VNTR以及COMT基因中的Val158Met，以研究决定DA水平的酶的遗传变异如何影响食物的摄入和营养状况。这项调查是对354名三至四岁巴西儿童的横断面检查。通过基于PCR的方法分析多态性。通过单因素方差分析或Kruskal Wallis检验比较了基因型中饮食和人体测量数据的平均值。 MAOAu-VNTR和COMT Val158Met多态性与男孩的可口食物摄入量有关。与短等位基因相比，MAOAu-VNTR长等位基因的存在与高脂类食物（LDF）的摄入有关（P = .009）; MAOAu-VNTR长等位基因的男性携带者中糖类食物（SDF）的摄入量也高于短等位基因的携带者（P = .034）。在女孩的样本中，MAOAu-VNTR多态性与食物摄入和营养状况无关。与Met / Met纯合子相比，COMT Val158Met Val等位基因携带者的LDF摄入量更高（P = .008）。这项研究首次表明，控制DA可用性的酶的遗传变异可能与确定儿童可口食物摄入量有关

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