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首页> 外文期刊>The Journal of Nutritional Biochemistry >Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol.
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Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol.

机译：白藜芦醇化学预防Apc Min 小鼠苯并（a）re诱导的结肠息肉。

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Human dietary exposure to benzo(a)pyrene (BaP) has generated interest with regard to the association of BaP with gastrointestinal carcinogenesis. Since colon cancer ranks third among cancer-related mortalities, it is necessary to evaluate the effect of phytochemicals on colon cancer initiation and progression. In this study, we investigated the preventive effects of resveratrol (RVT) on BaP-induced colon carcinogenesis in ApcMin mouse model. For the first group of mice, 100 mug BaP/kg body weight was administered to mice in peanut oil via oral gavage over a 60-day period. For the second group, RVT was coadministered with BaP at a dose of 45 mug/kg. For the third group, RVT was administered for 1 week prior to BaP exposure for 60 days. Jejunum, colon and liver were collected at 60 days post BaP and RVT exposure; adenomas in jejunum and colon were counted and subjected to histopathology. RVT reduced the number of colon adenomas in BaP+RVT-treated mice significantly compared to that in mice that received BaP alone. While dysplasia of varying degrees was noted in colon of BaP-treated mice, the dysplasias were of limited occurrence in RVT-treated mice. To ascertain whether the tumor inhibition is a result of altered BaP-induced toxicity of tumor cells, growth, apoptosis and proliferation of adenocarcinoma cells were assessed posttreatment with RVT and BaP. Cotreatment with RVT increased apoptosis and decreased cell proliferation to a greater extent than with BaP alone. Overall, our observations reveal that RVT inhibits colon tumorigenesis when given together with BaP and holds promise as a therapeutic agent
机译：人类饮食中苯并（a）re（BaP）的暴露引起了人们对BaP与胃肠道癌发生的关系的兴趣。由于结肠癌在癌症相关死亡率中排名第三，因此有必要评估植物化学物质对结肠癌的发生和发展的影响。在这项研究中，我们研究了白藜芦醇（RVT）对Apc Min 小鼠模型BaP诱导的结肠癌发生的预防作用。对于第一组小鼠，在60天的时间内通过口服管饲法向花生油中的小鼠施用100杯BaP / kg体重。对于第二组，RVT与BaP共同使用，剂量为45杯/千克。对于第三组，在BaP暴露60天之前给予RVT 1周。 BaP和RVT暴露后60天收集空肠，结肠和肝脏。对空肠和结肠中的腺瘤进行计数并进行组织病理学检查。与单独接受BaP的小鼠相比，RVT显着降低了BaP + RVT治疗的小鼠的结肠腺瘤数量。尽管在BaP治疗的小鼠结肠中发现了不同程度的异型增生，但在RVT治疗的小鼠中异型增生的发生率有限。为了确定肿瘤抑制作用是否是BaP诱导的肿瘤细胞毒性改变的结果，在用RVT和BaP治疗后评估了腺癌细胞的生长，凋亡和增殖。与单独使用BaP相比，与RVT共同治疗可更大程度地增加细胞凋亡并降低细胞增殖。总体而言，我们的观察结果表明，与BaP一起使用时，RVT可抑制结肠肿瘤发生，并有望作为治疗剂

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