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首页> 外文期刊>The Journal of Nutritional Biochemistry >Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice.
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Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice.

机译：肌醇的慢性治疗可减少雌性小鼠体内白色脂肪组织的积聚并改善胰岛素敏感性。

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摘要

Type 2 diabetes is a complex disease characterized by a state of insulin resistance in peripheral tissues such as skeletal muscle, adipose tissue or liver. Some inositol isomers have been reported to possess insulin-mimetic activity and to be efficient in lowering blood glucose level. The aim of the present study was to assess in mice the metabolic effects of a chronic treatment with myo-inositol, the most common stereoisomer of inositol. Mice given myo-inositol treatment (0.9 or 1.2 mg g--1 day--1, 15 days, orally or intraperitoneally) exhibited an improved glucose tolerance due to a greater insulin sensitivity. Mice treated with myo-inositol exhibited a decreased white adipose tissue accretion (--33%, P < .005) compared with controls. The decrease in white adipose tissue deposition was due to a decrease in adipose cell volume (--33%, P < .05), while no change was noticed in total adipocyte number. In skeletal muscle, in vivo as well as exvivomyo-inositol treatment increased protein kinase B/Akt phosphorylation under baseline and insulin-stimulated conditions, suggesting a synergistic action of myo-inositol treatment and insulin on proteins of the insulin signalling pathway. Myo-inositol could therefore constitute a viable nutritional strategy for the prevention and/or treatment of insulin resistance and type 2 diabetes. All rights reserved, Elsevier.
机译：2型糖尿病是一种复杂疾病，其特征在于周围组织（例如骨骼肌，脂肪组织或肝脏）的胰岛素抵抗状态。据报道，一些肌醇异构体具有模仿胰岛素的活性，并且在降低血糖水平方面是有效的。本研究的目的是评估小鼠肌醇（肌醇最常见的立体异构体）长期治疗的代谢作用。接受肌醇治疗的小鼠（口服或腹膜内注射0.9或1.2 mg g -1 天-1 15天）表现出更高的葡萄糖耐量胰岛素敏感性。与对照组相比，用肌醇治疗的小鼠表现出减少的白色脂肪组织积聚（-33％，P <.005）。白色脂肪组织沉积的减少是由于脂肪细胞体积的减少（-33％，P <.05），而总脂肪细胞数量没有变化。在骨骼肌中，体内以及体外肌醇治疗在基线和胰岛素刺激的条件下均增加了蛋白激酶B / Akt的磷酸化，表明肌醇治疗和胰岛素对胰岛素信号通路蛋白的协同作用。因此，肌醇可构成预防和/或治疗胰岛素抵抗和2型糖尿病的可行营养策略。保留所有权利，Elsevier。

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