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首页> 外文期刊>The Journal of Nutritional Biochemistry >Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice.
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Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice.

机译：来自苦瓜的生物活性物质可增强高脂饮食喂养小鼠骨骼肌中的胰岛素信号传导并调节其酰基肉碱含量。

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摘要

Bioactive components from bitter melon (BM) have been reported to improve glucose metabolism in vivo, but definitive studies on efficacy and mechanism of action are lacking. We sought to investigate the effects of BM bioactives on body weight, muscle lipid content and insulin signaling in mice fed a high-fat diet and on insulin signaling in L6 myotubes. Male C57BL/6J mice were randomly divided into low-fat diet control (LFD), high-fat diet (HFD) and HFD plus BM (BM) groups. Body weight, body composition, plasma glucose, leptin, insulin and muscle lipid profile were determined over 12 weeks. Insulin signaling was determined in the mouse muscle taken at end of study and in L6 myotubes exposed to the extract. Body weight, plasma glucose, insulin, leptin levels and HOMA-IR values were significantly lower in the BM-fed HFD group when compared to the HFD group. BM supplementation significantly increased IRS-2, IR beta, PI 3K and GLUT4 protein abundance in skeletal muscle, as well as phosphorylation of IRS-1, Akt1 and Akt2 when compared with HFD (P<.05 and P<.01). BM also significantly reduced muscle lipid content in the HFD mice. BM extract greatly increased glucose uptake and enhanced insulin signaling in L6 myotubes. This study shows that BM bioactives reduced body weight, improved glucose metabolism and enhanced skeletal muscle insulin signaling. A contributing mechanism to the enhanced insulin signaling may be associated with the reduction in skeletal muscle lipid content. Nutritional supplementation with this extract, if validated for human studies, may offer an adjunctive therapy for diabetes. All rights reserved, Elsevier.
机译：据报道，苦瓜（BM）的生物活性成分可改善体内葡萄糖代谢，但尚无确切的功效和作用机理研究。我们试图研究BM生物活性物质对高脂饮食小鼠的体重，肌肉脂质含量和胰岛素信号的影响以及对L6肌管中胰岛素信号的影响。将雄性C57BL / 6J小鼠随机分为低脂饮食对照组（LFD），高脂饮食（HFD）和HFD加BM（BM）组。在12周内确定体重，身体组成，血糖，瘦素，胰岛素和肌肉脂质分布。在研究结束时采集的小鼠肌肉中以及暴露于提取物的L6肌管中确定了胰岛素信号传导。与HFD组相比，BM喂养的HFD组的体重，血浆葡萄糖，胰岛素，瘦素水平和HOMA-IR值显着降低。与HFD相比，补充BM可以显着增加骨骼肌中IRS-2，IR beta，PI 3K和GLUT4蛋白的丰度，以及IRS-1，Akt1和Akt2的磷酸化（P <.05和P <.01）。 BM还显着降低了HFD小鼠的肌肉脂质含量。 BM提取物极大地增加了L6肌管中的葡萄糖摄取并增强了胰岛素信号传导。这项研究表明，BM生物活性物质可减轻体重，改善葡萄糖代谢并增强骨骼肌胰岛素信号传导。胰岛素信号增强的作用机制可能与骨骼肌脂质含量的减少有关。如果经人类研究验证，该提取物的营养补充可为糖尿病提供辅助治疗。保留所有权利，Elsevier。

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