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首页> 外文期刊>The Journal of Nutritional Biochemistry >Dietary modulation of clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitin-glucan fiber improves host metabolic alterations induced by high-fat diet in mice.
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Dietary modulation of clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitin-glucan fiber improves host metabolic alterations induced by high-fat diet in mice.

机译：几丁质-葡聚糖纤维对梭菌XIVa肠道细菌（ Roseburia spp。）的饮食调节可改善小鼠高脂饮食诱导的宿主代谢变化。

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Recent studies have provided new evidence that alterations in the composition of the gut microbiota - known as dysbiosis - participate in the development of obesity. The aim of the present study was to investigate the ability of chitin-glucan (CG) from a fungal source to modulate both the gut microbiota and glucose and lipid metabolism in high-fat (HF) diet-induced obese mice. Supplementation of the HF diet with fungal CG (10% w/w) induced caecal enlargement with prominent changes in gut microbiota: it restored the number of bacteria from clostridial cluster XIVa including Roseburia spp., which were decreased due to HF feeding. Furthermore, CG treatment significantly decreased HF-induced body weight gain, fat mass development, fasting hyperglycemia, glucose intolerance, hepatic triglyceride accumulation and hypercholesterolemia, independently of the caloric intake. All those parameters were negatively correlated with specific bacteria of clostridial cluster XIVa, i.e., Roseburia spp. (Pearson's correlations analysis). In contrast to prebiotics that more specifically target the bifidobacteria species, CG effects on obesity appear to be independent of the incretin glucagon-like peptide 1 (GLP-1) production, since portal GLP-1 and proglucagon (its precursor) expression were not modified by the dietary intervention. In conclusion, our findings support the view that chronic consumption of CG has potential beneficial effects with respect to the development of obesity and associated metabolic diabetes and hepatic steatosis, through a mechanism related to the restoration of the composition and/or the activity of gut bacteria, namely, bacteria from clostridial cluster XIVa
机译：最近的研究提供了新的证据，即肠道菌群组成的改变（称为营养不良）参与了肥胖的发展。本研究的目的是研究真菌来源的几丁质-葡聚糖（CG）调节高脂（HF）饮食诱导的肥胖小鼠的肠道菌群以及葡萄糖和脂质代谢的能力。 HF日粮添加真菌CG（10％w / w）导致盲肠肿大，肠道菌群发生明显变化：它恢复了梭菌簇XIVa的细菌数量，其中包括 Roseburia spp。，这些细菌数量有所减少由于HF进料。此外，CG治疗显着降低了HF引起的体重增加，脂肪形成，空腹高血糖，葡萄糖耐受不良，肝甘油三酸酯蓄积和高胆固醇血症，而与热量摄入无关。所有这些参数都与梭菌簇XIVa的特定细菌，即 Roseburia spp。负相关。 （Pearson的相关分析）。与更具体地针对双歧杆菌物种的益生元相比，CG对肥胖的影响似乎与肠降血糖素样胰高血糖素样肽1（GLP-1）的产生无关，因为未修饰门户GLP-1和胰高血糖素原（其前体）的表达通过饮食干预。总之，我们的发现支持这样的观点，即长期服用CG通过与肠道细菌的组成和/或活性恢复相关的机制，对肥胖症和相关的代谢性糖尿病和肝脂肪变性的发展具有潜在的有益作用。 ，即来自梭菌簇XIVa的细菌

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