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首页> 外文期刊>The Journal of Nutritional Biochemistry >HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults.
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HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults.

机译：HUM5007是产热化合物与3-乙酰基-7-氧代-脱氢表雄酮的新颖组合：每种都可增加超重成年人的静息代谢率。

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摘要

This study tested the hypothesis that 3-acetyl-7-oxo-dehydroepiandrosterone alone (7-Keto) and in combination with calcium citrate, green tea extract, ascorbic acid, chromium nicotinate and cholecalciferol (HUM5007) will increase the resting metabolic rate (RMR) of overweight subjects maintained on a calorie-restricted diet. In this randomized, double-blind, placebo-controlled, crossover trial, overweight adults on a calorie-restricted diet were randomized to three 7-day treatment periods with 7-Keto, HUM5007 or placebo. Resting metabolic rate was measured by indirect calorimetry at the beginning and end of each treatment period with a 7-day washout between testing periods. Of 45 subjects enrolled, 40 completed the study (30 women, 10 men; mean age, 38.5 years; mean mass index, 32.0 kg/m2). During the placebo treatment, RMR decreased by 3.9% (75+or-111 kcal/day; mean+or-S.D.); however, RMR increased significantly by 1.4% (21+or-115 kcal/day) and 3.4% (59+or-118 kcal/day) during the 7-Keto and HUM5007 treatment periods, respectively (each compared to placebo, P=.001). No significant differences were found between the treatment periods with respect to compliance or adverse events. In this study, the administration of HUM5007 or 7-Keto reversed the decrease in RMR normally associated with dieting. HUM5007 and 7-Keto increased RMR above basal levels and may benefit obese individuals with impaired energy expenditure. HUM5007 and 7-Keto were generally well tolerated and no serious adverse events were reported.
机译：这项研究检验了以下假设：3-乙酰基-7-氧代-脱氢表雄酮单独使用（7-酮），并与柠檬酸钙，绿茶提取物，抗坏血酸，烟酸铬和胆钙化固醇（HUM5007）联合使用会增加静息代谢率（RMR） ）保持热量限制饮食的超重受试者。在这项随机，双盲，安慰剂对照，交叉试验中，限制卡路里饮食的超重成年人被随机分为三个7天治疗期，分别使用7-酮，HUM5007或安慰剂。在每个治疗阶段的开始和结束时，通过间接量热法测量静息代谢率，在测试阶段之间进行7天冲洗。在登记的45位受试者中，有40位完成了研究（30位女性，10位男性;平均年龄，38.5岁;平均体重指数，32.0 kg / m2）。在安慰剂治疗期间，RMR下降了3.9％（75+或-111 kcal /天;平均值+或-S.D.）;但是，在7-Keto和HUM5007治疗期间，RMR分别显着增加了1.4％（21+或-115 kcal /天）和3.4％（59+或-118 kcal /天）（与安慰剂相比，P = .001）。在治疗期间之间在依从性或不良事件方面没有发现显着差异。在这项研究中，服用HUM5007或7-酮可逆转通常与节食有关的RMR下降。 HUM5007和7-Keto将RMR增加到基础水平以上，可能使能量消耗受损的肥胖个体受益。 HUM5007和7-酮的耐受性一般良好，没有严重不良反应的报道。

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