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首页> 外文期刊>The Journal of Nutritional Biochemistry >Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1.
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Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1.

机译：Cyanidin 3-葡萄糖苷可通过转录因子FoxO1减轻高脂饮食喂养和 db / db 小鼠的肥胖相关胰岛素抵抗和肝脂肪变性。

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摘要

Obesity is a major risk factor for the development of type 2 diabetes, and both conditions are now recognized to possess significant inflammatory components underlying their pathophysiologies. Here, we hypothesized that cyanidin 3-glucoside (C3G), a typical anthocyanin reported to possess potent anti-inflammatory properties, would ameliorate obesity-associated inflammation and metabolic disorders, such as insulin resistance and hepatic steatosis in mouse models of diabesity. Male C57BL/6J obese mice fed a high-fat diet for 12 weeks and genetically diabetic db/db mice at an age of 6 weeks received dietary C3G supplementation (0.2%) for 5 weeks. We found that dietary C3G lowered fasting glucose levels and markedly improved the insulin sensitivity in both high-fat diet fed and db/db mice as compared with unsupplemented controls. White adipose tissue messenger RNA levels and serum concentrations of inflammatory cytokines (tumor necrosis factor- alpha, interleukin-6, and monocyte chemoattractant protein-1) were reduced by C3G, as did macrophage infiltration in adipose tissue. Concomitantly, hepatic triglyceride content and steatosis were alleviated by C3G. Moreover, C3G treatment decreased c-Jun N-terminal kinase activation and promoted phosphorylation and nuclear exclusion of forkhead box O1 after refeeding. These findings clearly indicate that C3G has significant potency in antidiabetic effects by modulating the c-Jun N-terminal kinase/forkhead box O1 signaling pathway and the related inflammatory adipocytokines.
机译：肥胖是2型糖尿病发展的主要危险因素，现已公认这两种疾病均具有构成其病理生理学基础的重要炎症成分。在这里，我们假设花青素3-葡糖苷（C3G）是一种典型的花青素，据报道具有强效的抗炎特性，可以减轻肥胖相关的炎症和代谢紊乱，例如在糖尿病小鼠模型中的胰岛素抵抗和肝脂肪变性。饲喂高脂饮食12周的雄性C57BL / 6J肥胖小鼠和6周龄的遗传性糖尿病db / db小鼠接受5周的饮食C3G补充（0.2％）。我们发现，与未补充营养的对照组相比，高脂饮食喂养和db / db小鼠的饮食中C3G降低了空腹血糖水平并显着提高了胰岛素敏感性。 C3G降低了白色脂肪组织信使RNA水平和炎性细胞因子（肿瘤坏死因子-α，白细胞介素6和单核细胞趋化蛋白-1）的血清浓度，脂肪组织中的巨噬细胞浸润也降低了该水平。同时，C3G可减轻肝甘油三酯含量和脂肪变性。此外，C3G处理降低了进食后叉头箱O1的c-Jun N端激酶激活并促进了磷酸化和核排斥。这些发现清楚地表明，C3G通过调节c-Jun N末端激酶/叉头盒O1信号传导途径和相关的炎症性脂肪细胞因子，具有显着的抗糖尿病作用。

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