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首页> 外文期刊>The Journal of Nutritional Biochemistry >Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia.
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Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia.

机译：血清磷脂中的二十碳五烯酸与家族性高胆固醇血症患者的动脉粥样硬化脂蛋白谱有关。

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摘要

Familial hypercholesterolemia (FH) carries an increased vascular risk due to lifelong elevation of the number of circulating low-density lipoprotein (LDL) particles, but also to alterations in triglyceride and high-density lipoprotein (HDL) metabolism. Supplementation with eicosapentaenoic (EPA) or docosahexaenoic (DHA) acids reduced LDL particle number and/or increased LDL size in different populations, but studies in FH are scarce. We investigated cross-sectionally whether intake of EPA and DHA in the usual diet is associated with a less atherogenic lipoprotein profile in subjects with FH (n=215). Lipoprotein particle number and size distributions were assessed with nuclear magnetic resonance spectroscopy. EPA and DHA proportions in serum phosphatidylcholine, a biomarker of fish intake, were determined by gas chromatography. After adjusting for cardiovascular risk factors, including fasting triglycerides, serum phosphatidylcholine EPA (but not DHA) related inversely to medium VLDL, total LDL particle number and very small LDL, resulting in a net direct association with LDL size. Additionally, EPA was directly associated with concentrations of large HDL. We conclude that increased serum phosphatidylcholine EPA derived from seafood intake with the usual diet is associated with a less atherogenic lipoprotein profile in subjects with FH. Increased fish intake and/or EPA supplements might contribute to reduce the residual risk of statin-treated FH subjects
机译：家族性高胆固醇血症（FH）由于终生增加循环中的低密度脂蛋白（LDL）颗粒的数量，还伴随着甘油三酸酯和高密度脂蛋白（HDL）代谢的改变而增加了血管风险。在不同人群中补充二十碳五烯酸（EPA）或二十二碳六烯酸（DHA）酸可减少LDL颗粒数量和/或增加LDL大小，但是在FH中的研究很少。我们进行了横断面调查，在FH患者中（n = 215），日常饮食中EPA和DHA的摄入是否与动脉粥样硬化的脂蛋白分布减少有关。用核磁共振波谱法评估脂蛋白的颗粒数量和大小分布。通过气相色谱法测定血清磷脂酰胆碱（鱼类摄入的生物标志物）中的EPA和DHA比例。在调整了包括空腹甘油三酸酯在内的心血管危险因素后，血清磷脂酰胆碱EPA（但不是DHA）与中等VLDL，总LDL颗粒数和非常小的LDL成反比，从而导致与LDL大小的净直接相关。此外，EPA与大HDL浓度直接相关。我们得出的结论是，在患有FH的受试者中，通过日常饮食从海鲜中摄取的血清磷脂酰胆碱EPA含量增加与动脉粥样硬化的脂蛋白谱降低有关。鱼摄入量增加和/或EPA补充剂可能有助于降低他汀类药物治疗的FH受试者的残留风险

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