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首页> 外文期刊>The Journal of Nutritional Biochemistry >Methionine-dependent histone methylation at developmentally important gene loci in mouse preimplantation embryos
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Methionine-dependent histone methylation at developmentally important gene loci in mouse preimplantation embryos

机译：小鼠植入前胚胎中重要发育基因位点的蛋氨酸依赖性组蛋白甲基化

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摘要

The involvement of specific nutrients in epigenetic gene regulation is a possible mechanism underlying nutrition-directed phenotypic alteration. However, the involvement of nutrients in gene-specific epigenetic regulation remains poorly understood. Methionine has been received attention as a possible nutrient involved in epigenetic modifications, as it is a precursor of the universal methyl donor for epigenetic methylation of DNA and histones. In the present study, the disruption of methionine metabolism by ethionine, an antimetabolite of methionine, induced abnormally higher expression of genes related to cell lineage differentiation and resulted in impaired blastocyst development of mouse preimplantation embryos in vitro. These effects were mitigated by the presence of methionine. Importantly, ethionine treatment induced lower trimethylation of histone H3 lysine 9 but did not affect methylation of DNA in the promoter regions of the examined genes. These results demonstrated that intact methionine metabolism is required for proper epigenetic histone modifications and normal expression of developmentally important genes during preimplantation development. (C) 2015 Elsevier Inc. All rights reserved.
机译：表观遗传基因调控中特定营养素的参与是营养定向表型改变的潜在机制。然而，营养对基因特异性表观遗传调控的参与仍然知之甚少。蛋氨酸已作为表观遗传修饰中的一种可能的营养素而受到关注，因为它是DNA和组蛋白表观甲基化的通用甲基供体的前体。在本研究中，蛋氨酸的抗代谢物乙硫氨酸破坏蛋氨酸的代谢，诱导与细胞谱系分化相关的基因异常高表达，并导致体外小鼠胚胎植入前胚泡发育受损。蛋氨酸的存在减轻了这些影响。重要的是，乙硫氨酸处理诱导组蛋白H3赖氨酸9的较低的三甲基化作用，但不影响所检查基因的启动子区域DNA的甲基化作用。这些结果表明，在植入前发育过程中，适当的表观遗传组蛋白修饰和发育重要基因的正常表达需要完整的蛋氨酸代谢。 （C）2015 Elsevier Inc.保留所有权利。

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