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首页> 外文期刊>The Journal of Nutritional Biochemistry >Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives.
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Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives.

机译：与肿瘤细胞对姜黄素和姜黄素衍生物的敏感性或抗性有关的基因的药物基因组学确定。

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摘要

Curcuma longa L. has long been used as a medicinal plant in traditional Chinese medicine against abdominal disorders. Its active constituent curcumin has anti-inflammatory, chemopreventive and cytotoxic properties. In the present investigation, we have analyzed the cytotoxic activity of curcumin and four derivatives. Among these compounds, ethoxycurcumintrithiadiazolaminomethylcarbonate was the most cytotoxic one. The curcumin-type compounds were not cross-resistant to standard anticancer drugs and were not involved in ATP-binding cassette transporter-mediated multidrug resistance. A combined approach of messenger RNA-based microarray profiling, COMPARE analyses and signaling pathway analyses identified genes as determinants of sensitivity and resistance to curcumin and specific signaling routes involved in cellular response to curcumin. These genes may be useful as biomarkers to develop individualized treatment options in the future. From a nutritional point of view, it is a thriving perspective to further investigate whether C. longa may be used as a spice to improve cancer therapy.
机译：姜黄长期以来一直用作抗腹部疾病的中药药用植物。其活性成分姜黄素具有抗炎，化学预防和细胞毒性特性。在本研究中，我们分析了姜黄素和四种衍生物的细胞毒活性。在这些化合物中，乙氧基curcumintrithiadiadiazolaminomethylcarbonate是最具细胞毒性的化合物。姜黄素类化合物对标准抗癌药物无交叉耐药性，并且不参与ATP结合盒转运蛋白介导的多药耐药性。基于信使RNA的微阵列分析，COMPARE分析和信号通路分析的组合方法，将基因鉴定为对姜黄素的敏感性和抗性的决定因素，以及参与细胞对姜黄素反应的特定信号传导途径的决定因素。这些基因可能用作将来开发个性化治疗选择的生物标志物。从营养学的角度来看，进一步研究是否可以将长毛衣原体用作改善癌症治疗的香料是一个欣欣向荣的观点。

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