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首页> 外文期刊>The Journal of Nutritional Biochemistry >Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects.
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Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects.

机译：急性补充二十碳五烯酸会降低健康受试者的血小板微粒活性。

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Background: Dietary supplementation with omega-3 fatty acids has been associated with reduced incidence in thrombotic events. In addition, administration of n-3 polyunsaturated fatty acids (PUFAs) has been shown to rectify elevated platelet microparticle (MP) number and procoagulant activity in post myocardial infarction patients. However, it is unknown whether supplementation can alter these parameters in healthy individuals and if such effects are immediate or require long-term supplementation. We have previously demonstrated a gender-specific effect of LCn-3PUFA supplementation on platelet aggregation in healthy human subjects. Here we extend these findings to include the acute effects of supplementation with EPA- or DHA-rich oils on circulating MP levels and activity in healthy subjects. Design: A placebo-controlled trial was conducted in healthy males and females (n = 30). MP activity, MP levels and platelet aggregation were measured at 0 and 24 h postsupplementation with either a placebo or EPA- or DHA-rich oil. Results: Both EPA and DHA effectively reduced platelet aggregation at 24 h postsupplementation relative to placebo (--13.3%, P = .006 and --11.9%, P = .016, respectively), but only EPA reduced MP activity (--19.4%, P = .003). When grouped by gender, males showed a similar reduction in both platelet aggregation and MP activity (--20.5%, P = .008; --22%, P = .008) following EPA, while females showed significantly reduced platelet aggregation (--13.7%, P = .04) but not MP activity after DHA only. Conclusion: EPA and DHA exert gender-dependent effects on platelet aggregation and platelet MP activity, but not on MP levels. With respect to thrombotic disease risk, males may benefit more from EPA supplementation
机译：背景：膳食补充omega-3脂肪酸与血栓形成事件的发生率降低相关。此外，已证明在心肌梗死后患者中，使用n-3多不饱和脂肪酸（PUFA）可以纠正升高的血小板微粒（MP）数量和促凝血活性。但是，尚不清楚补充是否可以改变健康个体中的这些参数，以及这种作用是即时的还是需要长期补充的。先前我们已经证明了LCn-3PUFA补充剂对健康人受试者血小板聚集的性别特异性作用。在这里，我们将这些发现扩展到包括补充富含EPA或DHA的油对健康受试者体内循环MP水平和活性的急性影响。设计：在健康的男性和女性（n = 30）中进行了安慰剂对照试验。在补充安慰剂或富含EPA或DHA的油后0和24小时测量MP活性，MP水平和血小板聚集。结果：相对于安慰剂，EPA和DHA在补充后24 h均有效降低了血小板凝集（分别为--13.3％，P = .006和--11.9％，P = .016），但只有EPA降低了MP活性（- 19.4％，P = 0.003）。当按性别分组时，男性在EPA后显示出血小板凝集和MP活性的相似降低（--20.5％，P = .008; --22％，P = .008），而女性显示出显着降低的血小板凝集（- -13.7％，P = .04），但仅DHA后没有MP活性。结论：EPA和DHA对血小板聚集和血小板MP活性具有性别依赖性，但对MP水平无影响。关于血栓形成疾病的风险，男性可能会从EPA补充中受益更多

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