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首页> 外文期刊>The Journal of Nutritional Biochemistry >Extra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats
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Extra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats

机译：特级初榨橄榄油可增加棕色脂肪组织中解偶联蛋白1的含量，并增强大鼠的去甲肾上腺素和肾上腺素分泌

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摘要

The effects of extra virgin olive oil (EV-olive oil) on triglyceride metabolism were investigated by measuring the degree of thermogenesis in interscapular brown adipose tissue (IBAT) and the rates of noradrenaline and adrenaline secretions in rats, both in vivo and in situ. In Experiment 1 (in vivo), rats were given an isoenergetic high-fat diet (30% fat diet) containing corn oil, refined olive oil, or EV-olive oil. After 28 days of feeding, the final body weight, weight gain, energy efficiency, perirenal adipose tissue and epididymal fat pad and plasma triglyceride concentrations were the lowest in the rats fed the EV-olive oil diet. The content of uncoupling protein 1 (UCP1) in IBAT and the rates of urinary noradrenaline and adrenaline excretions were the highest in the rats fed the EV-olive oil diet. In Experiment 2 (in situ), the effects of the extract of the phenolic fraction from EV-olive oil and a compound having excellent characteristics as components of EV-olive oil, hydroxytyrosol, on noradrenaline and adrenaline secretions were evaluated. The intravenous administration of the extract of the phenolic fraction from EV-olive oil significantly increased plasma noradrenaline and adrenaline concentrations, whereas that of hydroxytyrosol had no effect. These results suggest that phenols except hydroxytyrosol in EV-olive oil enhance thermogenesis by increasing the UCP1 content in IBAT and enhancing noradrenaline and adrenaline secretions in rats.
机译：通过测量肩inter间褐色脂肪组织（IBAT）的生热程度以及大鼠体内和原位去甲肾上腺素和肾上腺素的分泌速率，研究了特级初榨橄榄油（EV-橄榄油）对甘油三酸酯代谢的影响。在实验1（体内）中，给大鼠提供了等能量高脂饮食（30％脂肪饮食），其中含有玉米油，精制橄榄油或EV橄榄油。饲喂28天后，在接受EV-橄榄油饮食的大鼠中，最终体重，体重增加，能量效率，肾周脂肪组织和附睾脂肪垫和血浆甘油三酸酯浓度最低。在饲喂EV-橄榄油油的大鼠中，IBAT中解偶联蛋白1（UCP1）的含量以及尿中去甲肾上腺素和肾上腺素的排泄率最高。在实验2中（原位），评估了来自EV-橄榄油的酚类馏分的提取物和具有优异特性的化合物作为EV-橄榄油，羟基酪醇的成分对去甲肾上腺素和肾上腺素分泌的影响。静脉注射EV橄榄油中的酚类成分提取物可显着提高血浆去甲肾上腺素和肾上腺素的浓度，而羟基酪醇则无作用。这些结果表明，EV-橄榄油中的除羟基酪醇以外的酚可通过增加IBAT中的UCP1含量并增强大鼠中的去甲肾上腺素和肾上腺素分泌来增强生热作用。

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