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首页> 外文期刊>The Journal of Nutritional Biochemistry >Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells.
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Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells.

机译：胡椒碱通过血红素加氧酶-1诱导听觉细胞保护顺铂诱导的凋亡。

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摘要

Piperine is a major component of black pepper, Piper nigrum Linn, used widely in traditional medicine. In this study, we examined whether piperine could protect House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against cisplatin-induced apoptosis through the induction of heme oxygenase (HO)-1 expression. Piperine (10-100 micro M) induced the expression of HO-1 in dose- and time-dependent manners. Piperine also induced antioxidant response element-luciferase and translocated nuclear factor-E2-related factor-2 (Nrf2) to nucleus. Piperine activated the c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase and p38 mitogen-activated protein kinase (MAPK) pathways, and the JNK pathway played an important role in piperine-induced HO-1 expression. Piperine protected the cells against cisplatin-induced apoptosis. The protective effect of piperine was abrogated by zinc protoporphyrin IX, an HO inhibitor, and antisense oligodeoxynucleotides against HO-1 gene. These results demonstrate that the expression of HO-1 by piperine is mediated by both JNK pathway and Nrf2, and the expression inhibits cisplatin-induced apoptosis in HEI-OC1 cells.
机译：胡椒碱是黑胡椒的主要成分，胡椒被广泛用于传统医学中。在这项研究中，我们检查了胡椒碱是否可以通过诱导血红素加氧酶（HO）-1的表达来保护House Ear Institute-Corti 1（HEI-OC1）细胞免受顺铂诱导的细胞凋亡。胡椒碱（10-100 micro M）以剂量和时间依赖性方式诱导HO-1的表达。胡椒碱还诱导抗氧化剂响应元件荧光素酶和核因子E2相关因子2（Nrf2）易位至核。胡椒碱激活c-Jun N端激酶（JNK），细胞外信号调节激酶和p38丝裂原活化蛋白激酶（MAPK）途径，并且JNK途径在胡椒碱诱导的HO-1表达中起重要作用。胡椒碱保护细胞免受顺铂诱导的细胞凋亡。胡椒碱IX的HO抑制剂和对HO-1基因的反义寡脱氧核苷酸取消了胡椒碱的保护作用。这些结果证明胡椒碱对HO-1的表达受JNK途径和Nrf2的介导，并且表达抑制了顺铂诱导的HEI-OC1细胞凋亡。

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