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首页> 外文期刊>The Journal of Nutritional Biochemistry >Iron and mechanisms of emotional behavior
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Iron and mechanisms of emotional behavior

机译：铁与情绪行为机制

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Iron is required for appropriate behavioral organization. Iron deficiency results in poor brain myelination and impaired monoamine metabolism. Glutamate and gamma-aminobutyric acid homeostasis is modified by changes in brain iron status. Such changes produce not only deficits in memory/learning capacity and motor skills, but also emotional and psychological problems. An accumulating body of evidence indicates that both energy metabolism and neurotransmitter homeostasis influence emotional behavior, and both functions are influenced by brain iron status. Like other neurobehavioral aspects, the influence of iron metabolism on mechanisms of emotional behavior is multifactorial: brain region-specific control of behavior, regulation of neurotransmitters and associated proteins, temporal and regional differences in iron requirements, oxidative stress responses to excess iron, sex differences in metabolism, and interactions between iron and other metals. To better understand the role that brain iron plays in emotional behavior and mental health, this review discusses the pathologies associated with anxiety and other emotional disorders with respect to body iron status. (C) 2014 Elsevier Inc. All rights reserved.
机译：适当的行为组织需要铁。铁缺乏症会导致大脑髓鞘变差和单胺代谢受损。谷氨酸和γ-氨基丁酸体内稳态通过脑铁状态的改变而改变。这种变化不仅会导致记忆/学习能力和运动技能的不足，还会导致情绪和心理问题。越来越多的证据表明，能量代谢和神经递质稳态均会影响情绪行为，而两种功能均受脑铁状态的影响。像其他神经行为方面一样，铁代谢对情绪行为机制的影响是多方面的：大脑特定区域的行为控制，神经递质和相关蛋白的调节，铁需求的时间和区域差异，对过量铁的氧化应激反应，性别差异代谢以及铁与其他金属之间的相互作用。为了更好地了解脑铁在情绪行为和心理健康中的作用，本综述讨论了与铁蛋白状态相关的焦虑症和其他情绪障碍相关的病理。 （C）2014 Elsevier Inc.保留所有权利。

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