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首页> 外文期刊>The Journal of Nutritional Biochemistry >Hippocampal apoptosis involved in learning deficits in the offspring exposed to maternal high sucrose diets
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Hippocampal apoptosis involved in learning deficits in the offspring exposed to maternal high sucrose diets

机译：海马细胞凋亡与母亲高蔗糖饮食接触后代的学习缺陷有关

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摘要

The hippocampus plays a crucial role in learning and memory, and neuronal apoptosis in the hippocampus contributes to learning deficits. Metabolism problems in pregnancy related to excessive fuel consumption (e.g., high fat, high sugar) may influence cognitive and behavioral functions in the offspring by affecting developing brain cells. This study determined the influence of maternal high sucrose (HS) diets on behavior and hippocampal neurons in the young offspring. The ratio of brain weight to body weight in the offspring exposed to prenatal HS diets was significantly decreased; the Morris water maze showed that the offspring exposed to prenatal HS diets exhibited increased escape latencies and path length during navigation testing, while there were no changes in time spent in the target quadrant and number of target approaches. In the offspring exposed to prenatal HS, TUNEL-positive cells were significantly increased in CA1, CA2 and CA3 of the hippocampus; protein expression of insulin-like growth factor-I, PI3K and phosphorylated Akt was significantly decreased, while caspase-3 and N-methyl-D-aspartate receptors were significantly increased in the hippocampus, and there was no change in expression of Bcl-2 and Akt The results demonstrated that prenatal HS diets could induce the spatial acquisition deficits in the young offspring associated with hippocampal apoptosis, and altered signaling factors for antiapoptosis in the hippocampus might play a critical role in cognition disorders in young children. (C) 2014 Published by Elsevier Inc.
机译：海马在学习和记忆中起着至关重要的作用，海马中的神经元凋亡导致学习缺陷。怀孕期间与过量燃料消耗有关的代谢问题（例如，高脂肪，高糖分）可能会通过影响发育中的脑细胞来影响后代的认知和行为功能。这项研究确定了母体高蔗糖（HS）饮食对幼仔行为和海马神经元的影响。暴露于产前HS饮食的后代的脑重与体重之比显着降低; Morris水迷宫显示，在导航测试期间，暴露于产前HS饮食的后代表现出逃逸潜伏期和路径长度增加，而目标象限所花费的时间和目标进场次数没有变化。在暴露于产前HS的后代中，海马CA1，CA2和CA3中TUNEL阳性细胞显着增加;胰岛素样生长因子-I，PI3K和磷酸化的Akt的蛋白表达明显降低，海马中的caspase-3和N-甲基-D-天冬氨酸受体明显升高，而Bcl-2的表达没有变化和Akt结果表明，产前HS饮食可能会导致与海马细胞凋亡相关的后代的空间获取不足，并且海马中抗凋亡的信号传导因子改变可能在幼儿认知障碍中起关键作用。 （C）2014由Elsevier Inc.发行

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