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首页> 外文期刊>The journal of obstetrics and gynaecology research >Problems in methods for the detection of significant proteinuria in pregnancy
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Problems in methods for the detection of significant proteinuria in pregnancy

机译：孕妇重大蛋白尿的检测方法存在问题

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Aim: The aim of this study was to underscore problems associated with the dipstick test and determination of protein concentration alone in spot-urine (P-test) compared with spot-urine protein-to-creatinine ratio (P/Cr test) and to determine whether urine collection for 24-h test was complete. Material and Methods: Dipstick and P/Cr tests were performed simultaneously in 357 random spot-urine specimens from 145 pregnant women, including 35 with pre-eclampsia. Positive results were defined as ≥1+ on dipstick test, protein concentration ≥30 mg/dL on P-test, and P/Cr ratio ≥0.27 (mg/mg) on P/Cr test. Sixty-four 24-h urine tests (quantification of protein in urine collected during 24 h) were performed in 27 of the 145 women. We assumed that P/Cr ratio ≥ 0.27 predicted significant proteinuria (urinary protein ≥ 0.3 g/day). The 24-h urine collection was considered incomplete when urinary creatinine excretion was <11.0 mg/kg/day or > 25.0 mg/kg/day. Results: Forty-four percent (69/156) of specimens with a positive test result on dipstick test contained protein < 30 mg/dL. Dipstick test was positive for 25.7% (69/269) of specimens with protein < 30 mg/dL and for 28.8% (79/274) of specimens with P/Cr ratio < 0.27. P-test results were positive for 7.3% (20/274) and negative for 18.1% (15/83) of specimens with P/Cr ratio < 0.27 and ≥0.27, respectively. Incomplete 24-h urine collection occurred in 15.6% (10/64) of 24-h urine tests. Daily urinary creatinine excretion was 702-1397 mg, while creatinine concentration varied from 16 mg/dL to 475 mg/dL in spot-urine specimens. Conclusion: Dipstick test and P-test were likely to over- and underestimate risks of significant proteinuria, respectively. The 24-h urine collection was often incomplete.
机译：目的：本研究的目的是强调与试纸测试和点尿液中蛋白质浓度的测定（P检验）相比，与点尿液蛋白与肌酐之比（P / Cr检验）有关的问题，以及确定用于24小时测试的尿液收集是否完成。材料和方法：对145名孕妇（其中35名先兆子痫）的357个随机尿样进行了试纸法和P / Cr测试。阳性结果定义为试纸测试≥1+，P测试蛋白浓度≥30mg / dL，P / Cr测试P / Cr比≥0.27（mg / mg）。 145名妇女中有27名进行了64次24小时尿液测试（对24小时内收集的尿液中蛋白质进行定量）。我们假设P / Cr比≥0.27预测为显着蛋白尿（尿蛋白≥0.3 g /天）。当尿肌酐排泄<11.0 mg / kg /天或> 25.0 mg / kg /天时，认为24小时尿液收集不完整。结果：百分之四十四（69/156）的标本在试纸测试中呈阳性结果，所含蛋白质<30 mg / dL。试纸测试对于蛋白质<30 mg / dL的标本为25.7％（69/269），对于P / Cr比<0.27的标本为28.8％（79/274）。 P / Cr比<0.27和≥0.27的标本的P检验结果分别为7.3％（20/274）和18.1％（15/83）阴性。 24小时尿液测试中有15.6％（10/64）的24小时尿液收集不完整。每日尿尿肌酐排泄量为702-1397 mg，而尿样尿样中的肌酐浓度从16 mg / dL到475 mg / dL不等。结论：试纸法和P检验可能分别高估和低估了严重蛋白尿的风险。 24小时尿液收集常常不完整。

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