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Aptamers-based assays for diagnostics, environmental and food analysis.

机译：基于适体的测定法，用于诊断，环境和食品分析。

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摘要

Aptamers are single stranded DNA or RNA ligands which can be selected for different targets starting from a huge library of molecules containing randomly created sequences. Aptamers have been selected to bind very different targets, from proteins to small organic dyes. In addition to the very important aspect of having an unlimited source of identical affinity recognition molecules available due to the selection process, aptamers can offer advantages over antibodies that make them very promising for analytical applications. The use of aptamers as therapeutic tools is nowadays well established. On the contrary, the analytical application of aptamers in diagnostic devices or in systems for environmental and food analysis, is still under investigation and the scientific community still need further research to demonstrate the advancements brought by this new kind of ligands. This review will focus on these latter applications with particular attention to the detection of food pathogens, terrorism threat agents, thrombin and cytokines.
机译：适体是单链DNA或RNA配体，可以从包含随机创建的序列的巨大分子库开始为不同的靶点选择适体。已经选择了适体来结合非常不同的靶标，从蛋白质到小的有机染料。除了非常重要的方面之外，由于选择过程的缘故，可提供无限数量的相同亲和力识别分子，适体可以提供优于抗体的优势，这使其在分析应用中非常有前途。如今，将适体用作治疗工具已经很成熟。相反，适体在诊断设备或环境和食品分析系统中的分析应用仍在研究中，科学界仍需要进一步研究以证明这种新型配体所带来的进步。这篇综述将集中于这些后期的应用，特别是对食物病原体，恐怖主义威胁因素，凝血酶和细胞因子的检测。

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