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首页> 外文期刊>Biomolecular engineering >Haemocompatibility of amorphous hydrogenated carbon thin films, optical properties and adsorption mechanisms of blood plasma proteins.
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Haemocompatibility of amorphous hydrogenated carbon thin films, optical properties and adsorption mechanisms of blood plasma proteins.

机译：非晶态氢化碳薄膜的血液相容性，血浆蛋白的光学性质和吸附机理。

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摘要

Haemocompatibility is one of the most important properties, together with the tissue compatibility and corrosion and wear resistance that determine the biocompatibility of the artificial implants. Carbon-based thin films, such as amorphous carbon (a-C) and amorphous hydrogenated diamond-like carbon (a-C:H or DLC) are considered as excellent candidates for use as biocompatible coatings on biomedical implants. The aim of this work is the comparative study of the haemocompatibility of the a-C:H thin films developed by magnetron sputtering under various deposition conditions, the development of a methodology in order to study the haemocompatibility of thin films, the optical properties of the adsorbed proteins (human serum albumin and fibrinogen) and their adsorption mechanisms. Haemocompatibility and the optical properties of a-C:H thin films and the adsorbed proteins were studied by spectroscopic ellipsometry (SE). The films grown under floating conditions performed better haemocompatibility compared with those deposited under application of bias voltage. In the range of vis-UV, proteins are transparent, while they present an absorption peak at higher energies, but except these characteristics, their optical functions are rather featureless. Adsorption mechanisms were studied through AFM technique too. AFM results are in accordance with those derived by SE. Combination of the two techniques gives us a more accurate description of protein adsorption mechanisms.
机译：血液相容性是最重要的特性之一，与组织相容性，腐蚀和耐磨性一起决定了人造植入物的生物相容性。碳基薄膜，例如无定形碳（a-C）和无定形氢化类金刚石碳（a-C：H或DLC）被认为是用作生物医学植入物上生物相容性涂层的极佳候选材料。这项工作的目的是对磁控溅射在各种沉积条件下开发的aC：H薄膜的血液相容性进行比较研究，研究用于研究薄膜的血液相容性的方法的发展，吸附蛋白的光学性质（人血清白蛋白和纤维蛋白原）及其吸附机理。用椭圆偏振光谱法研究了α-C：H薄膜的血液相容性和光学性质以及所吸附的蛋白质。与在偏置电压下沉积的薄膜相比，在浮动条件下生长的薄膜具有更好的血液相容性。在可见光范围内，蛋白质是透明的，尽管它们在较高的能量下会出现吸收峰，但是除了这些特性外，它们的光学功能也没有任何特征。也通过原子力显微镜技术研究了吸附机理。 AFM结果与SE得出的结果一致。两种技术的结合为我们提供了蛋白质吸附机理的更准确描述。

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