Two Approaches to Diverting the Course of a Free-Radical Cyclization:Application of Cyclopropylcarbinyl Radical Fragmentations and Allenes as Radical Acceptorst

Dexi Yang; Valerie Cwynar; Matthew G. Donahue; David J. Hart; Grace Mbogo

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Two Approaches to Diverting the Course of a Free-Radical Cyclization:Application of Cyclopropylcarbinyl Radical Fragmentations and Allenes as Radical Acceptorst

机译：转移自由基环化过程的两种方法：环丙基羰基自由基裂解和丙二烯作为自由基受体的应用

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Free radical cyclization of 4 and 7 gave the expected cyclization-reduction products (5 and 8) alongwith considerable amounts of products derived from a cyclization-atom transfer-secondarycyclization process (6 and 9). Two approaches to avoiding these unexpected products were explored.Use of a cyclopropylcarbinyl fragmentation avoided the secondary cyclization reaction (25 or43 — 26 or 44), whereas use of an allene as a radical acceptor avoided the atom-transfer reactionaltogether (49 — 52).

机译：4和7的自由基环化产生了预期的环化还原产物（5和8），以及可观的衍生自环化-原子转移-二次环化过程的产物（6和9）。探索了避免这些意外产物的两种方法。使用环丙基羰基片段避免了第二次环化反应（25或43-26或44），而使用亚勒烯作为自由基受体则完全避免了原子转移反应（49-52）。

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《The Journal of Organic Chemistry》 |2009年第22期|共7页
作者
Dexi Yang; Valerie Cwynar; Matthew G. Donahue; David J. Hart; Grace Mbogo;
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正文语种 eng
中图分类有机化学;
关键词
products; acceptor; fragmentation;

机译：产品;受体;碎片;

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1. Two Approaches to Diverting the Course of a Free-Radical Cyclization:Application of Cyclopropylcarbinyl Radical Fragmentations and Allenes as Radical Acceptorst [J] . Dexi Yang, Valerie Cwynar, Matthew G. Donahue, The Journal of Organic Chemistry . 2009,第22期

机译：转移自由基环化过程的两种方法：环丙基羰基自由基裂解和丙二烯作为自由基受体的应用
2. Tandem enyne allene-radical cyclization: low-temperature approaches to benz[e]indene and indene compounds [J] . Janet Wisniewski Grissom, Detlef Klingberg, Dahai huang The Journal of Organic Chemistry . 1997,第3期

机译：串联烯炔丙二烯自由基环化：苯并[e]茚和茚化合物的低温方法
3. Intramolecular free-radical cyclization reactions on pentose sugars for the synthesis of carba-LNA and carba-ENA and the application of their modified oligonucleotides as potential RNA targeted therapeutics [J] . Zhou C., Chattopadhyaya J. Chemical Reviews . 2012,第7期

机译：戊糖上的分子内自由基环化反应用于合成carba-LNA和carba-ENA及其修饰的寡核苷酸作为潜在的RNA靶向治疗剂的应用
4. Free-Radical Synthesis of Functional Polymers Involving Addition-Fragmentation Reactions [C] . P.Chaumont, D.Colombani, L.Boiteau J.P.Lamps, National meeting of the American Chemical Society . 1998

机译：涉及加成-断裂反应的功能聚合物的自由基合成
5. gamma-Functionalization of Enones and Regioselective Cyclopropylcarbinyl Radical Fragmentations. [D] . Liu, Xiaoguang. 2016

机译：烯的γ-官能化和区域选择性的环丙基羰基自由基断裂。
6. Advancements in Free-Radical Pathologies and an Important Treatment Solution with a Free-Radical Inhibitor [O] . RC Petersen, MS Reddy, P-R Liu -1

机译：自由基病理学的进展和带有自由基抑制剂的重要治疗方案
7. Molecular Orbital Calculations of Ring Opening of the Isoelectronic Cyclopropylcarbinyl Radical, Cyclopropoxy Radical, and Cyclopropylaminium Radical Cation Series of Radical Clocks [O] . -1

机译：异形环丙基羰基自由基，环丙酮基自由基和环丙基氨基鎓自由基阳离子阳离子系列的分子轨道计算

Two Approaches to Diverting the Course of a Free-Radical Cyclization:Application of Cyclopropylcarbinyl Radical Fragmentations and Allenes as Radical Acceptorst

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