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首页> 外文期刊>The Journal of Prosthetic Dentistry >Platelet concentration and its effect on bone formation in calvarial defects: an experimental study in rabbits.
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Platelet concentration and its effect on bone formation in calvarial defects: an experimental study in rabbits.

机译：血小板浓度及其对颅骨缺损骨形成的影响：在兔中的实验研究。

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STATEMENT OF PROBLEM: The use of the platelet concentration technique is widespread in dental implant surgery. However, its effect or mechanism is not clearly understood. PURPOSE: This study introduced an animal model for the platelet concentration technique and evaluated its effect on bone formation with natural cancellous bovine bone mineral. MATERIAL AND METHODS: Adult New Zealand white rabbits were used as the animal model. A density gradient medium was used to obtain a constant platelet count for the preparation of platelet concentrates. In the experimental group, natural cancellous bovine bone mineral with added platelet concentrates was grafted onto critically sized bony defects of the rabbit calvarium. Bone formation in the tissue sections was evaluated with soft x-ray imaging and computer tomography. RESULTS: The average platelet count of the rabbit platelet concentrates was 1487 x 10(3)/microL (287% concentrated). In all the tested parameters, greater bone densities were obtained in grafts that were combined with platelet concentrates. CONCLUSION: This study showed that the rabbit is a useful animal model for studying the platelet concentration technique. When combined with grafts of natural cancellous bovine bone mineral, the technique increased bone formation.
机译：问题陈述：血小板浓缩技术的使用在牙科植入手术中得到了广泛的应用。但是，其作用或机理尚不清楚。目的：本研究介绍了一种用于血小板浓缩技术的动物模型，并评估了其对天然松质牛骨矿物质对骨形成的影响。材料与方法：以成年新西兰白兔为动物模型。使用密度梯度介质获得恒定的血小板计数以制备血小板浓缩物。在实验组中，将天然的松质牛骨矿物质和添加的血小板浓缩物移植到家兔颅骨的临界大小的骨缺损上。用软X射线成像和计算机断层摄影术评估组织切片中的骨形成。结果：兔浓缩血小板的平均血小板计数为1487 x 10（3）/ microL（287％浓缩）。在所有测试参数中，与血小板浓缩液结合的移植物中均获得了更高的骨密度。结论：本研究表明兔是研究血小板浓缩技术的有用动物模型。当与天然松质牛骨矿物质移植物结合使用时，该技术可增加骨形成。

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