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首页> 外文期刊>The Journal of Urology >Periprostatic nerve blockade for transrectal ultrasound guided biopsy of the prostate: a randomized, double-blind, placebo controlled study.
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Periprostatic nerve blockade for transrectal ultrasound guided biopsy of the prostate: a randomized, double-blind, placebo controlled study.

机译：经直肠超声引导下前列腺穿刺活检的前列腺周围神经阻滞：一项随机，双盲，安慰剂对照研究。

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PURPOSE: We performed a randomized, double-blind, placebo controlled study to assess the safety and efficacy of periprostatic anesthesia administration during prostate biopsy. MATERIALS AND METHODS: From May to November 2000 transrectal ultrasound guided prostate biopsy was performed in 132 consecutive men due to an abnormal digital rectal examination and/or elevated prostate specific antigen. During biopsy 66 patients each were randomly assigned to receive an injection of 1% lidocaine or normal saline. Immediately after biopsy the pain score was recorded independently by patients and the physician using a 10-point linear scale. In addition, patients were given a descriptive questionnaire to be completed at home and mailed back within 2 weeks of biopsy. RESULTS: Mean patient perceived pain scores plus or minus standard deviation of 2.7 +/- 0.21 in the lidocaine and 4.7 +/- 0.26 in the saline groups were significantly different (p <0.0001), as were mean physician perceived scores of 2.9 +/- 0.27 and 5.1 +/- 0.34, respectively (p = 0.0001). Mean questionnaire scores for pain during biopsy of 2.3 +/- 0.13 in the lidocaine and 3.1 +/- 0.18 in the saline groups were also significantly different (p = 0.0006), as were mean questionnaire scores for pain after biopsy of 1.8 +/- 0.11 and 2.3 +/- 0.13, respectively (p <0.006). There were no adverse effects of injection. CONCLUSIONS: Our results show a significant benefit of periprostatic anesthesia over placebo in a randomized double-blind trial. This safe, simple and rapid technique should be applied at transrectal ultrasound guided prostate biopsy to limit undue patient discomfort.
机译：目的：我们进行了一项随机，双盲，安慰剂对照的研究，以评估前列腺穿刺术期间前列腺周围麻醉的安全性和有效性。材料与方法：2000年5月至2000年11月，由于直肠指检异常和/或前列腺特异性抗原升高，对132例连续男性进行了经直肠超声引导的前列腺穿刺活检。在活检期间，有66位患者被随机分配接受1％利多卡因或生理盐水注射。活检后立即由患者和医生使用10点线性量表独立记录疼痛评分。此外，还给患者提供了描述性问卷，以便他们在家完成并在活检后2周内寄回。结果：利多卡因患者的平均疼痛感知评分加或减标准偏差为2.7 +/- 0.21，生理盐水组为4.7 +/- 0.26显着不同（p <0.0001），医师感知的平均评分为2.9 + / -分别为0.27和5.1 +/- 0.34（p = 0.0001）。利多卡因活检期间疼痛的平均问卷评分为2.3 +/- 0.13，生理盐水组的平均问卷评分为3.1 +/- 0.18（p = 0.0006），活检后疼痛的平均问卷评分为1.8 +/-。分别为0.11和2.3 +/- 0.13（p <0.006）。没有注射不良反应。结论：我们的结果显示，在一项随机双盲试验中，前列腺癌麻醉优于安慰剂。这种安全，简单，快速的技术应在经直肠超声引导下的前列腺穿刺活检中应用，以限制患者的不适感。

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