• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of sexual medicine >Nerve growth factor modulation of the cavernous nerve response to injury.
【24h】

Nerve growth factor modulation of the cavernous nerve response to injury.

机译：神经生长因子调节海绵体神经对损伤的反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

INTRODUCTION: Surgical therapies for prostate cancer and other pelvic malignancies often result in neuronal damage and debilitating loss of sexual function due to cavernous nerve (CN) trauma. Advances in the neurobiology of growth factors have heightened clinical interest in the development of protective and regenerative neuromodulatory strategies targeting CN recovery following injury. AIM: The aim of this review was to offer an examination of current and future nerve growth factor (NGF) modulation of the CN response to injury with a focus on brain-derived nerve growth factor (BDNF), growth differentiation factor-5 (GDF-5), and neurturin (NTN). METHODS: Information for this presentation was derived from a current literature search using the National Library of Medicine PubMed Services producing publications relevant to this topic. Search terms included neuroprotection, nerve regeneration, NGFs, neurotrophic factors, BDNF, GDF-5, NTN, and CNs. MAIN OUTCOME MEASURES: Basic science studies satisfying the search inclusion criteria were reviewed. RESULTS: In this session, BDNF, atypical growth factors GDF-5 and NTN, and their potential influence upon CN recovery after injury are reviewed, as are the molecular pathways by which their influence is exerted. CONCLUSIONS: Compromised CN function is a significant cause of erectile dysfunction development following prostatectomy and serves as the primary target for potential neuroprotective or regenerative strategies utilizing NGFs such as BDNF, GDF-5, and NTN, and/or targeted novel therapeutics modulating signaling pathways.
机译：简介：针对前列腺癌和其他盆腔恶性肿瘤的外科治疗通常会由于海绵状神经（CN）创伤而导致神经元损害和虚弱的性功能丧失。生长因子神经生物学的进展已经提高了针对损伤后CN恢复的保护性和再生性神经调节策略的开发的临床兴趣。目的：本综述的目的是检查目前和将来神经损伤因子对神经反应的神经生长因子（NGF）调节，重点是脑源性神经生长因子（BDNF），生长分化因子5（GDF） -5）和神经氨酸（NTN）。方法：本次演讲的信息来自使用国立医学图书馆PubMed Services进行的当前文献检索，产生了与此主题相关的出版物。搜索词包括神经保护，神经再生，NGF，神经营养因子，BDNF，GDF-5，NTN和CN。主要观察指标：审查符合检索纳入标准的基础科学研究。结果：在本次会议中，对BDNF，非典型生长因子GDF-5和NTN及其对损伤后CN恢复的潜在影响进行了综述，并探讨了影响其作用的分子途径。结论：受损的CN功能是前列腺切除术后勃起功能障碍发展的重要原因，并且是利用NGF如BDNF，GDF-5和NTN和/或靶向信号通路的靶向新疗法的潜在神经保护或再生策略的主要靶点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号