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首页> 外文期刊>The journal of sexual medicine >Testosterone levels in males with type 2 diabetes and their relationship with cardiovascular risk factors and cardiovascular disease.
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Testosterone levels in males with type 2 diabetes and their relationship with cardiovascular risk factors and cardiovascular disease.

机译：2型糖尿病男性的睾丸激素水平及其与心血管危险因素和心血管疾病的关系。

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INTRODUCTION: One of the factors involved in type 2 diabetes in males is a reduction in levels of testosterone, which has been shown to predict resistance to insulin and the development of cardiovascular diseases. AIM: To assess the levels of testosterone in patients with type 2 diabetes and to evaluate their relationship with cardiovascular risk factors, peripheral arterial disease (PAD) and silent myocardial ischemia (SMI). METHODS: Total testosterone and sex hormone binding globulin were measured and free and bioavailable testosterones were calculated using Vermeulen's formula. Levels of total testosterone > or = 12 nmol/L or free testosterone > 225 pmol/L were considered normal. PAD was evaluated using the ankle-brachial index. SMI was assessed using a baseline ECG, Doppler echocardiogram, 24-hour electrocardiogram (ECG) Holter, exercise stress testing (EST), nuclear stress (if EST inconclusive), and if the result was positive, a coronary angiography. MAIN OUTCOME MEASURES: PAD, SMI, testosterone, erectile dysfunction, 24-hour blood pressure Holter, body mass index (BMI), waist circumference, lipid profile, insulin resistance, chronic inflammation, United Kingdom Prospective Diabetes Study cardiovascular risk score, nephropathy, retinopathy, and neuropathy. RESULTS: The study population was composed of 192 diabetic males with a mean age of 56.1 +/- 7.8 years and without a history of vascular disease. Twenty-three percent presented total testosterone below normal and 21.8% presented low free testosterone. BMI, waist circumference, neuropathy, triglycerides, C-reactive protein (CRP), glucose, insulin, and HOMA-IR were found to be significantly incremented with respect to subjects with normal testosterone. There was a negative correlation of HOMA-IR with total testosterone. PAD was detected in 12% and SMI in 10.9% of subjects, and differences were not related to testosterone levels. CONCLUSIONS: We have verified the prevalence of low testosterone levels in male patients with type 2 diabetes and have related them to variations in BMI, waist circumference, neuropathy, triglycerides, CRP, glucose, insulin and HOMA-IR, but not with an increase of SMI or PAD.
机译：简介：男性2型糖尿病所涉及的因素之一是睾丸激素水平的降低，这已被证明可以预测对胰岛素的抵抗和心血管疾病的发展。目的：评估2型糖尿病患者的睾丸激素水平，并评估其与心血管危险因素，外周动脉疾病（PAD）和无症状心肌缺血（SMI）的关系。方法：测量总睾丸激素和性激素结合球蛋白，并根据Vermeulen公式计算游离和可利用的睾丸激素。总睾丸激素水平>或= 12 nmol / L或游离睾丸激素> 225 pmol / L被认为是正常的。使用踝肱指数评估PAD。使用基线心电图，多普勒超声心动图，24小时心电图（ECG）动态心电图，运动压力测试（EST），核应力（如果EST不确定）来评估SMI，如果结果为阳性，则进行冠状动脉造影。主要观察指标：PAD，SMI，睾丸激素，勃起功能障碍，24小时血压动态心电图，体重指数（BMI），腰围，脂质分布，胰岛素抵抗，慢性炎症，英国前瞻性糖尿病研究心血管风险评分，肾病，视网膜病变和神经病。结果：该研究人群由192名糖尿病男性组成，平均年龄为56.1 +/- 7.8岁，无血管疾病史。 23％的人表示总睾丸激素低于正常水平，而21.8％的人表示游离睾丸激素水平低。相对于睾丸激素正常的受试者，发现BMI，腰围，神经病，甘油三酸酯，C反应蛋白（CRP），葡萄糖，胰岛素和HOMA-IR显着增加。 HOMA-IR与总睾丸激素呈负相关。 PAD检出率为12％，SMI检出率为10.9％，差异与睾丸激素水平无关。结论：我们已经验证了男性2型糖尿病患者睾丸激素水平低的患病率，并将其与BMI，腰围，神经病，甘油三酸酯，CRP，葡萄糖，胰岛素和HOMA-IR的变化相关，但并没有增加SMI或PAD。

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