• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of sexual medicine >Association analysis of endothelial nitric oxide synthase G894T gene polymorphism and erectile dysfunction complaints in a population-based survey.
【24h】

Association analysis of endothelial nitric oxide synthase G894T gene polymorphism and erectile dysfunction complaints in a population-based survey.

机译：一项基于人群的调查中，内皮型一氧化氮合酶G894T基因多态性与勃起功能障碍的关联分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

INTRODUCTION: Erectile dysfunction (ED) is a common disorder leading to a serious, negative impact on the quality of the patient's life. The gene encoding endothelial nitric oxide synthase (eNOS) is an interesting candidate gene for understanding the physiopathology of ED, as it is involved in the catalytic production of nitric oxide (NO), the neurotransmitter that plays a critical role in penile tumescence and erection. AIM: To evaluate a potential association between the G894T polymorphism in the eNOS gene and ED complaints in a population-based sample in Sao Paulo, Brazil. MAIN OUTCOME MEASURES: The prevalence of ED complaints was estimated according to the answer to the question How would you describe your ability to get and keep an erection that is adequate for satisfactory intercourse?" ED was considered to be present if the response was "sometimes" or "never." METHODS: A total of 449 men were enrolled in the study and answered an eight-item questionnaire to ascertain sexual performance/ED and satisfaction. The eNOS G894T polymorphism was genotyped using a standard polymerase chain reaction method. RESULTS: Univariate analysis demonstrated that ED was associated with diabetes, hypertension, sleep apnea severity, increasing age and body mass index, as well as testosterone levels (P < 0.05). Forward multiple regression models indicated that age was the only independent factor associated with ED in this population (odds ratio = 1.09; 95% CI 1.06-1.11; P < 0.0001). Genotypic and allelic analyses provided no evidence for an association between this polymorphism and the risk for ED complaints in this sample. Population stratification did not affect the association test results. CONCLUSIONS: This is the first study to examine the effect of polymorphisms in the eNOS gene and the risk for ED utilizing a case-control approach in the Brazilian population. Our results do not support a major role for eNOS gene polymorphisms in ED in this population.
机译：简介：勃起功能障碍（ED）是一种常见疾病，会对患者的生活质量造成严重的负面影响。编码内皮型一氧化氮合酶（eNOS）的基因是理解ED生理病理学的有趣候选基因，因为它参与一氧化氮（NO）的催化生成，而一氧化氮在阴茎勃起和勃起中起关键作用。目的：在巴西圣保罗的一个基于人群的样本中，评估eNOS基因中G894T多态性与ED投诉之间的潜在关联。主要观察指标：根据以下问题的答案估算出ED的患病率：您如何描述自己获得并保持足以使人满意的性交的勃起能力？”如果答复为“有时”，则认为存在ED方法：共有449名男性参加了这项研究，并回答了一个八项问卷，以确定性能力/ ED和满意度。采用标准的聚合酶链反应法对eNOS G894T多态性进行基因分型。单因素分析表明ED与糖尿病，高血压，睡眠呼吸暂停严重程度，年龄和体重指数增加以及睾丸激素水平有关（P <0.05），正向多元回归模型表明年龄是与ED相关的唯一独立因素。该人群（优势比= 1.09; 95％CI 1.06-1.11; P <0.0001）。基因型和等位基因分析没有提供证据表明这种多态性之间存在关联欺诈和本样本中ED投诉的风险。人群分层不影响联想测试结果。结论：这是第一项研究，通过病例对照方法研究了巴西人群中eNOS基因多态性的影响和ED的风险。我们的结果不支持该人群中ED中eNOS基因多态性的主要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号