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首页> 外文期刊>The journal of sexual medicine >II. Slow oscillations in vaginal blood flow: regulation of vaginal blood flow patterns in rat by central and autonomic mechanisms.
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II. Slow oscillations in vaginal blood flow: regulation of vaginal blood flow patterns in rat by central and autonomic mechanisms.

机译：二。阴道血流缓慢振荡：通过中枢和自主神经机制调节大鼠阴道血流模式。

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INTRODUCTION: A new method for assessing female sexual arousal through changes in slow oscillatory patterns in vaginal blood flow was first described in the previous manuscript [1]. This method was translational and discriminated between normal healthy volunteers and women with female sexual arousal disorder. AIM: These studies addressed the influence of autonomic and central nervous systems on slow vaginal blood flow oscillations in rats. METHODS: Vaginal blood flow oscillations were measured in urethane-anesthetized rodents using laser Doppler flowmetry. Acquired data were filtered for frequency analysis range of 0.013-2.5 Hz. MAIN OUTCOME MEASURES: Data were assessed for changes in a high frequency range (HF = 0.6-2.5 Hz), and low frequency range (LF = 0.013-0.6 Hz). RESULTS: The basal HF oscillatory component of vaginal blood flow was primarily vagally mediated, although could be modulated pharmacologically with p-chloroamphetamine in the absence of vagal innervation. The LF component could be modulated by antagonists of noradrenergic receptors but did not appear to be dependent upon tonic activation of sympathetic circuitry. The non-selective dopamine receptor agonist apomorphine induced changes in vaginal blood flow oscillations consistent with sexual arousal during metestrus in the presence of the peripheral antagonist domperidone but not in the presence of the centrally acting antagonist haloperidol. Electrical stimulation of the paraventricular nucleus (PVN) of the hypothalamus induced an anti-arousal response in vaginal blood flow oscillations. These data demonstrated that manipulation of the central nervous system alone (via centrally acting apomorphine or electrical stimulation of the PVN) could produce either a pro-arousal or an anti-arousal response in vaginal blood flow oscillations. Alterations in the LF/HF ratio measured from vaginal laser Doppler flowmetry were independently regulated from vasculature in the trunk, the tongue, and electrocardiogram-derived heart rate variability, and were independent of overall vasocongestion of the vagina as measured by mean blood flow. CONCLUSIONS: These data indicated that slow oscillations in vaginal blood flow from rodents may be utilized as an animal model of female sexual arousal. Changes in these oscillations are driven by the central nervous system and modulated by the autonomic nervous system.
机译：前言[1]首先介绍了一种通过阴道血流中缓慢振荡模式的变化来评估女性性唤起的新方法。这种方法是可转换的，可以区分正常健康志愿者和患有女性性唤起障碍的女性。目的：这些研究解决了自主神经和中枢神经系统对大鼠阴道缓慢血流振荡的影响。方法：使用激光多普勒血流仪在氨基甲酸乙酯麻醉的啮齿动物中测量阴道血流振荡。过滤所获得的数据以进行0.013-2.5 Hz的频率分析范围。主要观察指标：评估数据在高频范围（HF = 0.6-2.5 Hz）和低频范围（LF = 0.013-0.6 Hz）中的变化。结果：虽然在没有迷走神经支配的情况下，可以用对氯苯丙胺进行药理调节，但阴道血流的基础HF振荡成分主要是由阴道传导。 LF成分可以由去甲肾上腺素能受体的拮抗剂调节，但似乎并不依赖于交感神经回路的强直激活。非选择性的多巴胺受体激动剂阿扑吗啡在存在外周拮抗剂多潘立酮的情况下引起与在睾丸发生性刺激时的性唤醒相一致的阴道血流振荡变化，但在存在中枢作用的拮抗剂氟哌啶醇的情况下则不然。下丘脑室旁核（PVN）的电刺激在阴道血流振荡中引起抗唤醒反应。这些数据表明，仅对中枢神经系统进行操纵（通过中枢作用的阿扑吗啡或PVN的电刺激）可能会在阴道血流振荡中产生先激反应或反激反应。阴道激光多普勒血流仪测量的LF / HF比值的变化独立于躯干，舌头的脉管系统和源自心电图的心率变异性进行调节，并且与通过平均血流量测量的阴道总体血管阻塞无关。结论：这些数据表明，来自啮齿动物的阴道血流的缓慢振荡可以用作女性性唤起的动物模型。这些振荡的变化由中枢神经系统驱动，并由自主神经系统调节。

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