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首页> 外文期刊>The journal of sexual medicine >Selective serotonin reuptake inhibitor-induced sexual dysfunction.
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Selective serotonin reuptake inhibitor-induced sexual dysfunction.

机译：选择性5-羟色胺再摄取抑制剂引起的性功能障碍。

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INTRODUCTION: Sexual dysfunctions are often present in subjects with mood disturbances; however. antidepressants can induce per se sexual dysfunctions. AIM: To explore the relationship between the use of selective serotonin reuptake inhibitors (SSRIs), non-SSRIs antidepressants and benzodiazepines (BDZ), hormonal parameters, and reported sexual dysfunction (as assessed by the Structured Interview on Erectile Dysfunction [SIEDY]) in male subjects with comparable psychopathological symptoms (as assessed by the Middlesex Hospital Questionnaire [MHQ] a self-reported test for the screening of mental disorders in a non-psychiatric setting). METHODS: A consecutive series of 2,040 (mean age 51 +/- 13 years) male patients with sexual dysfunction was studied. MAIN OUTCOME MEASURES: Several hormonal and biochemical parameters were investigated, along with SIEDY and the MHQ. RESULTS: Higher prolactin was observed only in patients using SSRIs, whereas no other hormonal difference was found after adjustment for confounders. Use of SSRIs was associated with a twofold risk for patient hypoactive sexual desire and with a higher impairment of reported erectile function. However, no difference in penile blood flow was observed. A very high risk (sevenfold) for delayed ejaculation (DE) was observed in SSRI users. Interestingly, the association with the mild, but not severe, form of DE was observed also in subjects using non-SSRI antidepressants (3.35 [1.48-7.59]; P < 0.005). Different life stressors and relational parameters were also associated with SSRI use. SSRI users reported less enjoyment with masturbation and decreased partner desire and climax. Conversely, a lack of significant association was observed among BDZ or non-SSRI antidepressant users and all the aforementioned life-stressors and relational parameters. CONCLUSIONS: SSRIs can negatively affect all the steps of the male sexual response cycle (desire-arousal-excitement-orgasm). SSRI-associated sexual dysfunction has a deleterious effect on both auto- and couple-erotic performances. Conversely, other antidepressants and BDZ are less often associated with sexual impairment.
机译：简介：性功能障碍常出现在情绪障碍的受试者中。然而。抗抑郁药本身可引起性功能障碍。目的：探讨选择性5-羟色胺再摄取抑制剂（SSRIs），非SSRIs抗抑郁药和苯二氮卓类药物（BDZ），激素参数和所报告的性功能障碍之间的关系（根据勃起功能障碍[SIEDY]结构性访谈评估）具有类似精神病理症状的男性受试者（由Middlesex Hospital问卷[MHQ]评估，这是一项针对非精神病患者筛查精神障碍的自我报告测试）。方法：连续研究了2,040名（平均年龄为51 +/- 13岁）男性性功能障碍患者。主要观察指标：研究了几种激素和生化参数，以及SIEDY和MHQ。结果：仅在使用SSRI的患者中观察到较高的催乳激素，而在对混杂因素进行校正后，未发现其他激素差异。使用SSRIs与患者性欲减退的双重风险以及所报告的勃起功能受损较高有关。然而，未观察到阴茎血流的差异。在SSRI用户中观察到极高的延迟射精（DE）风险（七倍）。有趣的是，在使用非SSRI抗抑郁药的受试者中也观察到与轻度但不严重的DE的相关性（3.35 [1.48-7.59]; P <0.005）。不同的生活压力源和相关参数也与SSRI的使用有关。 SSRI用户报告说手淫的乐趣减少，伴侣的欲望和高潮减少。相反，在BDZ或非SSRI抗抑郁药使用者以及所有上述生活压力源和相关参数之间观察到缺乏显着关联。结论：SSRIs可对男性性反应周期的所有步骤（欲望-兴奋-兴奋-性高潮）产生负面影响。与SSRI相关的性功能障碍对自动和夫妻性爱表演均具有有害作用。相反，其他抗抑郁药和BDZ较少与性功能障碍相关。

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