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首页> 外文期刊>The journal of sexual medicine >Successful transcutaneous electrical nerve stimulation in two women with restless genital syndrome: the role of adelta- and C-nerve fibers.
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Successful transcutaneous electrical nerve stimulation in two women with restless genital syndrome: the role of adelta- and C-nerve fibers.

机译：两名患有躁动不安生殖器综合征的女性成功地经皮电神经刺激：δ和C神经纤维的作用。

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INTRODUCTION: Currently, efficacious treatment of restless genital syndrome (ReGS) is not available. AIM: This study aimed to report the results of transcutaneous electrical nerve stimulation (TENS) for ReGS, being a combination of genital dysesthesias, imminent and/or spontaneous orgasms, and/or restless legs, and/or overactive bladder. METHODS: Two women with ReGS were referred to our clinic. In-depth interview, routine and hormonal investigations, electroencephalography, magnetic resonance imaging (MRI) of the brain and pelvis, manual examination of the ramus inferior of the pubic bone, and sensory testing of genital dermatomes were performed. Conventional TENS (frequency: 110 Hz; pulse width: 80 milliseconds) was applied bilaterally at the region of the pudendal dermatome in which immediate reduction of genital sensations occurred. Patients were instructed for self-application of TENS each day for 2 months. MAIN OUTCOME MEASURES: Oral report, questionnaires on frequency of imminent and/or spontaneous orgasms, combined with questions on intensity of restless genital feelings, restless leg syndrome (RLS), overactive bladder syndrome (OAB), and satisfaction with TENS treatment. RESULTS: ReGS in a 56-year-old woman manifested as multiple spontaneous orgasms, RLS, and OAB. TENS applied to the sacral region resulted in immediate reduction of complaints and a 90% reduction of spontaneous orgasms, RLS, and OAB in 2 months. ReGS in a 61-year-old woman manifested as a continuous restless genital feeling, imminent orgasms, and OAB. TENS applied to the pubic bone resulted in a complete disappearance of restlessness in the genital area as well as OAB complaints in 2 months. Both women reported to be very satisfied and did not want to stop TENS treatment. CONCLUSIONS: Conventional TENS treatment is a promising therapy for ReGS, but further controlled research is warranted. Preorgasmic and orgasmic genital sensations in ReGS are transmitted by Adelta and C fibers and are inhibited by Abeta fibers. A neurological hypothesis on the pathophysiology of ReGS encompassing its clinical symptomatology, TENS, and drug treatment is put forward.
机译：简介：目前，尚无有效的躁动性生殖器综合症（ReGS）治疗方法。目的：该研究旨在报告经皮神经电刺激（TENS）治疗ReGS的结果，该结果是生殖器感觉异常，即将发生和/或自发性高潮，和/或腿部躁动和/或膀胱活动过度的综合表现。方法：将两名患有ReGS的女性转诊至我们的诊所。进行了深入的访谈，常规和激素检查，脑电图，大脑和骨盆的磁共振成像（MRI），耻骨下支的人工检查以及生殖器皮层的感官测试。常规的TENS（频率：110 Hz;脉冲宽度：80毫秒）在阴部皮刀的双侧应用，该区域立即发生了生殖器感觉下降。指导患者每天自我应用TENS，持续2个月。主要观察指标：口头报告，即将来临和/或自发性高潮发生频率的问卷，以及有关不安的生殖器感觉强度，不安的腿综合征（RLS），膀胱过动症（OAB）和对TENS治疗的满意度的问题。结果：一名56岁女性的ReGS表现为多个自发性高潮，RLS和OAB。 TENS应用于骨区域可在2个月内立即减少抱怨，并将自发性高潮，RLS和OAB减少90％。一名61岁女性的ReGS表现为持续不安的生殖器感觉，即将发生的性高潮和OAB。将TENS应用于耻骨会导致两个月内生殖器区域的躁动完全消失，以及OAB症状消失。两名妇女都表示非常满意，不想停止TENS治疗。结论：传统的TENS治疗是ReGS的有前途的治疗方法，但有必要进行进一步的对照研究。 ReGS中的高潮前和高潮生殖器感觉通过Adelta和C纤维传播，并被Abeta纤维抑制。提出了有关ReGS病理生理学的神经学假设，包括其临床症状，TENS和药物治疗。

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