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首页> 外文期刊>The journal of sexual medicine >Sex hormone levels, genetic androgen receptor polymorphism, and anxiety in >/=50-year-old males.
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Sex hormone levels, genetic androgen receptor polymorphism, and anxiety in >/=50-year-old males.

机译：> / = 50岁男性的性激素水平，遗传雄激素受体多态性和焦虑症。

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INTRODUCTION: While associations between somatic changes and sex hormone levels in aging men have been explored in many studies, the association of testosterone and estradiol with psychic symptoms other than depression and the role of the genetically determined CAG repeat (CAGn) polymorphism of the androgen receptor (AR) have received much less attention. AIM: The purpose of this article is to investigate the associations between general anxiety, phobic anxiety and panic with sex hormone levels and the genetic androgen receptor polymorphism in aging males. METHODS: This cross-sectional study of males aged >/=50 years included 120 consecutive patients of the Department of Psychosomatics and Psychotherapy, 76 consecutive patients of the Andrology Clinic, and 100 participants from the general population; all of them completed the Brief Symptom Inventory (BSI), the Aging Males' Symptoms (AMS) Scale, and the Patient Health Questionnaire (PHQ-9). Morning blood samples were analyzed for total and free testosterone, estradiol, sex hormone-binding globulin (SHBG), and the CAGn AR polymorphism. Psychosomatic patients also underwent psychiatric assessment. MAIN OUTCOME MEASURES: Scores on the Anxiety subscales of the BSI and PHQ, Anxiety disorders according to International Classification of Diseases, 10th revision (ICD-10). RESULTS: The two clinical samples had significantly longer CAGn of the AR and higher anxiety levels compared to the population sample. Anxiety scores were positively correlated with CAGn in psychosomatic patients and in andrological patients, in the latter also with estradiol levels, while the population sample showed no significant correlations between anxiety scores, CAGn and sex hormones. Anxiety cases according to BSI, PHQ, and ICD-10 had significantly longer CAGn of the AR when compared to the other participants, but there were no significant differences in testosterone or free testosterone levels. CONCLUSIONS: Our results indicate that genetically determined long CAGn of the AR is an independent risk factor for higher anxiety, panic and phobic anxiety levels.
机译：简介：尽管在许多研究中都探讨了衰老男性的体细胞变化与性激素水平之间的关联，但睾丸激素和雌二醇与除抑郁症以外的心理症状的关联以及雄激素受体的基因确定的CAG重复（CAGn）多态性的作用（AR）受到的关注要少得多。目的：本文的目的是研究一般性焦虑，恐惧和恐慌与性激素水平之间的关系，以及老年男性的遗传雄激素受体多态性。方法：这项对年龄≥50岁的男性进行的横断面研究包括120名连续的精神病学和心理治疗学系患者，76名连续的男科诊所患者和100名普通人群。他们都完成了简要症状量表（BSI），老年男性症状量表（AMS）量表和患者健康问卷（PHQ-9）。分析了早晨的血液样本中的总睾丸激素和游离睾丸激素，雌二醇，性激素结合球蛋白（SHBG）和CAGn AR多态性。心身患者也接受了精神病学评估。主要观察指标：根据国际疾病分类，第十版（ICD-10），对BSI和PHQ的焦虑量表进行评分，对焦虑症进行评分。结果：与人群样本相比，这两个临床样本的AR的CAGn明显更长，焦虑水平更高。心身患者和男科患者的焦虑评分与CAGn呈正相关，后者与雌二醇水平也呈正相关，而人群样本显示焦虑评分，CAGn与性激素之间无显着相关性。与其他参与者相比，根据BSI，PHQ和ICD-10的焦虑症患者的AR CAGn明显更长，但睾丸激素或游离睾丸激素水平没有显着差异。结论：我们的结果表明，遗传确定的AR的长CAGn是导致较高的焦虑，惊恐和恐惧性焦虑水平的独立危险因素。

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