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首页> 外文期刊>The journal of sexual medicine >Sacro-lumbar intersegmental spinal reflex in autonomic pathways mediating female sexual function.
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Sacro-lumbar intersegmental spinal reflex in autonomic pathways mediating female sexual function.

机译：auto腰段节段性脊柱反射在调节女性性功能的自主神经通路中。

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INTRODUCTION: Autonomic neurons in paracervical ganglia mediating vasodilation in the female reproductive tract receive inputs from both midlumbar and sacral spinal levels. However, it is not known how the lumbar pathways are activated. AIM: This study tested whether stimulation of pudendal sensory nerve could activate lumbar spinal outflows to paracervical ganglia via a spinal reflex pathway. METHODS: Isolated spinal cords with attached peripheral nerves were removed from urethane-anesthetized female guinea pigs and perfused via the aorta with physiological salt solution. Spinal pathways to midlumbar preganglionic neurons were tested by recording extracellular compound action potentials (CAPs) in lumbar splanchnic or distal hypogastric nerves after electrical stimulation of thoracic spinal cord or the pudendal nerve. CAPs also were recorded from pelvic nerves after pudendal nerve stimulation. Sensory neurons were retrogradely traced from the pudendal nerve and characterized immunohistochemically. MAIN OUTCOME MEASURES: Activation of preganglionic neurons projecting from midlumbar spinal cord to paracervical ganglia following stimulation of pudendal sensory nerves in isolated preparations. RESULTS: Thoracic spinal cord stimulation produced CAPs in hypogastric nerves that were abolished by transection of L3 lumbar splanchnic nerves. Pudendal nerve stimulation produced CAPs in L3 lumbar splanchnic, hypogastric, and pelvic nerves, demonstrating an ascending intersegmental spinal circuit to midlumbar levels in addition to the sacral spinal circuit. These CAPs in hypogastric nerves were enhanced by bicuculline (10 microM), blocked by tetrodotoxin (1 microM) but were not affected by hexamethonium (200 microM). Retrograde axonal tracing revealed four groups of sensory neurons in S3 dorsal root ganglia that were distinguished immunohistochemically. CONCLUSION: Midlumbar preganglionic neurons projecting to paracervical ganglia regulating blood flow and motility in the female reproductive tract can be activated by an ascending intersegmental spinal pathway from pudendal sacral inputs, which is inhibited by local spinal circuits. This pathway will help understand pathological conditions affecting reproductive function.
机译：简介：介导女性生殖道血管舒张的子宫颈旁神经节中的自主神经元从腰椎中部和骨脊髓水平接受输入。但是，还不知道腰椎通路如何被激活。目的：本研究测试了对阴部感觉神经的刺激是否可以通过脊柱反射途径激活腰椎向颈旁神经节的脊柱流出。方法：从经尿烷麻醉的雌性豚鼠中分离出附有周围神经的脊髓，并经主动脉灌注生理盐溶液。通过记录电刺激胸脊髓或阴部神经后的内脏或远端胃下神经中的细胞外复合动作电位（CAPs），测试了通往腰中神经节前神经元的脊髓途径。阴部神经刺激后，还从盆腔神经记录了CAP。从阴部神经逆行追溯感觉神经元，并进行免疫组织化学鉴定。主要观察指标：在分离的制剂中刺激阴部感觉神经后，从腰中脊髓向颈旁神经节突出的神经节前神经元激活。结果：胸脊髓刺激在下腹神经中产生了CAPs，而横断L3腰内脏神经将其消除。阴部神经刺激在L3腰内脏，下胃和骨盆神经中产生了CAP，这表明除了spin部脊柱回路外，节段性脊柱回路上升到腰中段。胃底神经中的这些CAP通过双小分子（10 microM）增强，被河豚毒素（1 microM）阻断，但不受六甲铵（200 microM）影响。逆行轴突追踪显示S3背根神经节中的4组感觉神经元在免疫组织化学上有所区别。结论：腰lum前神经节神经元投射到子宫颈旁神经节，调节女性生殖道的血流和运动，可通过阴部s骨输入的节段性脊髓间通路来激活，而该通路被局部脊髓回路抑制。该途径将有助于了解影响生殖功能的病理状况。

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