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首页> 外文期刊>The journal of sexual medicine >Testosterone reference ranges in normally cycling healthy premenopausal women.
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Testosterone reference ranges in normally cycling healthy premenopausal women.

机译：正常骑车的健康绝经前女性的睾丸激素参考范围。

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INTRODUCTION: At present, there are no well-accepted reference ranges for serum testosterone concentrations in women. AIM: The aim of this study was to determine the reference ranges for serum testosterone and sex hormone-binding globulin (SHBG) in premenopausal women with normal menstrual cycles. METHODS: We measured serum total, free, and bioavailable testosterone and SHBG concentrations in 161 healthy, normally cycling women (18-49 years). Morning blood samples were collected during follicular, mid-cycle, and luteal phases of the menstrual cycle and analyzed using validated methods. Mean, median, and weighted average hormone levels across menstrual cycle phases as well as percentiles for a typical 30-year-old woman were determined. MAIN OUTCOME MEASURES: Age-related serum levels of total, free, and bioavailable testosterone and SHBG levels in normally cycling premenopausal women. RESULTS: Serum testosterone concentrations exhibited an age-related decline, whereas SHBG remained relatively stable across studied age ranges. Reference ranges for total, free, and bioavailable testosterone and SHBG were established using 5th and 95th percentiles. The estimated 5th and 95th percentiles for a 30-year-old woman were: testosterone, 15-46 ng/dL (520-1595 pmol/L); free testosterone, 1.2-6.4 pg/mL (4.16-22.2 pmol/L); calculated free testosterone, 1.3-5.6 pg/mL (4.5-19.4 pmol/L); bioavailable testosterone, 1.12-7.62 ng/dL (38.8-264.21 pmol/L); and SHBG 18-86 nmol/L. The variations of hormones and SHBG across menstrual cycle were consistent with previous literature. CONCLUSIONS: Reference ranges for free, total, and bioavailable testosterone and SHBG were established in premenopausal women using validated immunoassays and an adequate number of subjects consistent with recommendations by the National Committee for Clinical Laboratory Standards. The increase in testosterone in the mid-cycle period is relatively small compared with the overall variability, so these reference ranges can be applied irrespective of the day in the menstrual cycle the sample has been taken.
机译：简介：目前，尚无女性血清睾丸激素浓度的公认参考范围。目的：本研究的目的是确定月经周期正常的绝经前妇女血清睾丸激素和性激素结合球蛋白（SHBG）的参考范围。方法：我们测量了161名健康，正常骑自行车的妇女（18-49岁）的血清总，游离和可生物利用的睾丸激素和SHBG浓度。在月经周期的卵泡期，中期和黄体期采集早晨血样，并使用经过验证的方法进行分析。确定了典型的30岁女性在月经周期各阶段的平均，中位数和加权平均激素水平以及百分位。主要观察指标：正常自行车停经前妇女的年龄相关血清总，游离和可生物利用的睾丸激素水平以及SHBG水平。结果：血清睾丸激素浓度表现出与年龄相关的下降，而SHBG在所研究的年龄范围内保持相对稳定。使用第5个和第95个百分位数确定总，游离和可生物利用的睾丸激素和SHBG的参考范围。对于30岁的女性，估计的第5个和第95个百分位数是：睾丸激素15-46 ng / dL（520-1595 pmol / L）;游离睾丸激素1.2-6.4 pg / mL（4.16-22.2 pmol / L）;计算的游离睾丸激素1.3-5.6 pg / mL（4.5-19.4 pmol / L）;生物利用睾丸激素，1.12-7.62 ng / dL（38.8-264.21 pmol / L）;和SHBG 18-86 nmol / L。月经周期中激素和SHBG的变化与以前的文献一致。结论：采用经验证的免疫测定方法，在绝经前妇女中建立了游离，总和可生物利用的睾丸激素和SHBG的参考范围，并根据国家临床实验室标准委员会的建议确定了足够数量的受试者。与总体变异性相比，在周期中期睾丸激素的增加相对较小，因此可以使用这些参考范围，而与月经周期中采集的日期无关。

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