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首页> 外文期刊>The journal of sexual medicine >Primary lifelong delayed ejaculation: characteristics and response to bupropion.
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Primary lifelong delayed ejaculation: characteristics and response to bupropion.

机译：原发性终身延迟射精：特征和对安非他酮的反应。

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INTRODUCTION: In contrast to premature ejaculation and secondary delayed ejaculation (DE), primary lifelong DE has not been studied extensively. In addition, there is no approved drug treatment. AIMS: To explore the clinical and laboratory characteristics of a series of men complaining of lifelong DE and to report the response to bupropion. METHODS: Nineteen consecutive men with primary lifelong DE were prospectively enrolled in this study. Study group was compared with an age-matched group of 19 healthy men. Both groups underwent history taking, physical examination, International Index of Erectile Function (IIEF), anxiety, and depression scores, ejaculation latency time (IELT) using stop watch and measurement of serum prolactin (PRL) and serum total testosterone (T). Patients received open-label bupropion-SR 150 mg/day for 2 months. MAIN OUTCOME MEASURES: Stopwatch-measured IELT values, global efficacy question, IIEF, anxiety, and depression scores. RESULTS: The mean age was 30.8 +/- 5.5 year (range 25-42 years). Men with DE exhibited significantly higher masturbatory activity during marital period, lower night emissions, longer IELT, lower orgasmic, and intercourse satisfaction domains of IIEF, higher anxiety and depression scores compared with the controls (all P<0.05). Both serum T and PRL levels did not differ significantly between patients and controls (all P<0.05). Four DE patients (21%) showed history of infertility. The percentage of DE men rating control over ejaculation as "fair to good" increased from 0 to 21.1% after bupropion therapy. The fold decreases of the geometric mean IELT was 0.74 after treatment. The intercourse satisfaction and the orgasmic domains of IIEF and depression score were significantly improved from baseline in the bupropion group (all P<0.05). CONCLUSIONS: Lifelong DE is mainly associated with higher and idiosyncratic masturbatory activity, lower night emissions, infertility, longer IELT, lower orgasmic, and intercourse satisfaction domains of IIEF, higher anxiety and depression scores. Bupropion-SR in a daily dosage of 150 mg seemed to be of limited benefit in lifelong DE.
机译：简介：与早泄和继发性延迟射精（DE）相比，原发性终生DE尚未得到广泛研究。此外，没有批准的药物治疗方法。目的：探讨一系列抱怨终身DE的男性的临床和实验室特征，并报告对安非他酮的反应。方法：前瞻性纳入本研究的连续19名原发性终生DE男性。将研究组与年龄匹配的19名健康男性进行比较。两组均接受历史记录，体格检查，国际勃起功能指数（IIEF），焦虑和抑郁评分，射精潜伏期时间（IELT）并使用秒表并测量血清催乳素（PRL）和血清总睾丸激素（T）。患者接受开放标签的安非他酮-SR 150毫克/天，持续2个月。主要观察指标：秒表测量的IELT值，整体疗效问题，IIEF，焦虑和抑郁评分。结果：平均年龄为30.8 +/- 5.5岁（范围25-42岁）。与对照组相比，DE男性在婚姻期间表现出明显更高的手淫活动，更低的夜间排放，更长的IELT，更低的性高潮和IIEF的性交满意度，更高的焦虑和抑郁评分（所有P <0.05）。患者和对照组之间的血清T和PRL水平均无显着差异（均P <0.05）。 4名DE患者（21％）有不孕史。在安非他酮治疗后，DE男性对射精的控制程度为“公平到良好”的百分比从0增加到21.1％。处理后，几何平均IELT的倍数降低为0.74。安非他酮组的性交满意度和IIEF的高潮域以及抑郁评分均较基线水平有明显改善（所有P <0.05）。结论：终身DE主要与较高和特发性的手淫活动，较低的夜间排放，不育，较长的IELT，较低的性高潮和IIEF的性交满意度，较高的焦虑和抑郁评分有关。每日剂量150 mg的安非他酮-SR对终生DE的益处似乎有限。

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