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首页> 外文期刊>The journal of sexual medicine >Programming effects of antenatal corticosteroids exposure in male sexual behavior.
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Programming effects of antenatal corticosteroids exposure in male sexual behavior.

机译：产前皮质类固醇暴露对男性性行为的编程影响。

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INTRODUCTION: Brain regions implicated in sexual behavior begin to differentiate in the last trimester of gestation. Antenatal therapy with corticosteroids is often used in clinical practice during this period to accelerate lung maturation in preterm-risk pregnancies. Clinical and animal studies highlighted major behavioral impairments induced later in life by these treatments, especially when synthetic corticosteroids are used. AIM: To evaluate the implications of acute prenatal treatment with natural vs. synthetic corticosteroids on adult male rat sexual behavior and its neurochemical correlates. METHODS: Twelve pregnant Wistar rats were injected with dexamethasone (DEX-1 mg/kg), corticosterone (CORT-25 mg/kg), or saline on late gestation (pregnancy days 18 and 19). Following this brief exposure to corticosteroids, we assessed the sexual behavior of the adult male progeny and subsequently associated these behaviors with the levels of catecholamines and mRNA of dopamine and androgen receptors (AR) in brain regions relevant for sexual behavior. MAIN OUTCOME MEASURES: Sexual behavior of adult male offspring was assessed by exposure to receptive females. This was associated with serum testosterone levels and levels of catecholamines (determined by high-performance liquid chromatography) and dopamine and AR mRNA expression (real-time polymerase chain reaction [PCR]) in brain regions implicated in sexual behavior. RESULTS: Prenatal DEX exposure resulted in a decreased number and increased mounts and intromissions latencies in adulthood. These findings were associated with decreased levels of serum testosterone and increased hypothalamic expression of AR mRNA. DEX animals also displayed lower dopamine levels and higher dopamine receptor mRNA expression both in hypothalamus and nucleus accumbens (NAcc). The milder phenotype of CORT animals was associated only with decreased dopamine levels in NAcc. CONCLUSION: Antenatal corticotherapy programs adult male sexual behavior through changes in specific neuronal and endocrine mediators. Importantly, equipotent doses of CORT trigger less detrimental consequences than DEX, emphasizing the differential impact of activation of the different corticosteroid receptors.
机译：简介：与性行为有关的大脑区域在妊娠的最后三个月开始分化。在此期间的临床实践中，通常在早期临床实践中使用皮质类固醇进行产前治疗，以加速早产风险妊娠中的肺成熟。临床和动物研究强调了这些疗法在生命的后期会引起重大的行为障碍，尤其是在使用合成皮质类固醇时。目的：评估天然与合成皮质类固醇急性产前治疗对成年雄性大鼠性行为及其神经化学相关性的影响。方法：在妊娠后期（妊娠第18和19天）给12只Wistar怀胎大鼠注射地塞米松（DEX-1 mg / kg），皮质酮（CORT-25 mg / kg）或生理盐水。在短暂暴露于皮质类固醇之后，我们评估了成年雄性子代的性行为，随后将这些行为与大脑中与性行为相关的儿茶酚胺水平以及多巴胺和雄激素受体（AR）的mRNA水平相关联。主要观察指标：成年雄性后代的性行为是通过暴露于雌性雌性来评估的。这与涉及性行为的大脑区域的血清睾丸激素水平和儿茶酚胺水平（由高效液相色谱法测定）以及多巴胺和AR mRNA表达（实时聚合酶链反应[PCR]）有关。结果：产前DEX暴露导致成年人数减少，坐骑和内倾潜伏期延长。这些发现与血清睾丸激素水平降低和下丘脑AR mRNA表达增加有关。 DEX动物在下丘脑和伏隔核（NAcc）中也显示出较低的多巴胺水平和较高的多巴胺受体mRNA表达。 CORT动物的较轻表型仅与NAcc中多巴胺水平降低有关。结论：产前皮质疗法通过改变特定的神经元和内分泌介质来对成年男性的性行为进行编程。重要的是，等剂量的CORT引发的不良后果要比DEX少，强调了不同皮质类固醇受体激活的不同影响。

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