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首页> 外文期刊>The journal of sexual medicine >Albuminuria is an Independent Risk Factor of Erectile Dysfunction in Men with Type 2 Diabetes
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Albuminuria is an Independent Risk Factor of Erectile Dysfunction in Men with Type 2 Diabetes

机译：蛋白尿是2型糖尿病男性勃起功能障碍的独立危险因素

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Introduction. Erectile dysfunction (ED) is a frequent comorbidity in men with diabetes and is frequently overlooked in routine clinical evaluation. Albuminuria, a marker of endothelial dysfunction, may link to ED. Aim. The study evaluated the association of albuminuria with risk factors of ED in men with type 2 diabetes. Methods. The diagnosis of ED was based on a self-administered questionnaire containing Sexual Health Inventory for Men. Urinary albumin excretion rate was determined by urine albumin-to-creatinine ratio (UACR) in spot urine. Main Outcome Measures. The clinical variables and diabetes-associated complications to risk of ED were evaluated. Results. Of 666 patients who received the questionnaire, 455 patients completed it. Among them, 82.0%, 28.1%, and 35.8% reported having ED, severe ED, and albuminuria, respectively. The UACR level was significantly higher in ED (0.20±0.83) and severe ED (0.34±1.18) groups compared with non-ED group (0.07±0.33). The presence of albuminuria adjusted for age and duration of diabetes was significantly associated with ED (OR=2.76), and macroalbuminuria has stronger impact (OR=4.49) than microalbuminuria (OR=2.48). The other associated risk factors included hypertension, higher level of systolic blood pressure, lower level of serum hemoglobin, and estimated glomerular filtration rate. The presence of retinopathy, neuropathy, insulin therapy, using calcium channel blocker, and higher level of HbA1c further correlated with severe ED. Men with severe ED have higher prevalence of subnormal testosterone than the no ED patients. The high sensitivity C-reactive protein level, and the presence of metabolic syndrome were not risk factors. The 211 nonrespondents to the questionnaire had similar or worse risk profiles compared with the ED patients. Conclusion. Albuminuria is an important independent risk factor of ED in men with diabetes after adjustment of age and diabetes mellitus duration. Identification and control of albuminuria and other associated risk factors might play a role in the prevention or reversal of ED.
机译：介绍。勃起功能障碍（ED）是糖尿病男性的常见合并症，在常规临床评估中经常被忽略。蛋白尿是内皮功能障碍的标志，可能与ED有关。目标。该研究评估了2型糖尿病男性中蛋白尿与ED危险因素的关系。方法。 ED的诊断基于一份包含男性性健康清单的自我管理问卷。尿白蛋白排泄率由尿液中尿白蛋白/肌酐比值（UACR）确定。主要观察指标。评估临床变量和糖尿病相关并发症对ED危险的影响。结果。在666名接受调查表的患者中，有455名患者完成了调查表。其中，报告有ED，严重ED和白蛋白尿的分别为82.0％，28.1％和35.8％。 ED（0.20±0.83）和重度ED（0.34±1.18）组的UACR水平明显高于非ED组（0.07±0.33）。根据糖尿病的年龄和持续时间进行调整的白蛋白尿的存在与ED显着相关（OR = 2.76），而巨蛋白尿比白蛋白尿（OR = 2.48）具有更强的影响（OR = 4.49）。其他相关的危险因素包括高血压，较高的收缩压，较低的血清血红蛋白和估计的肾小球滤过率。视网膜病变，神经病，胰岛素治疗，使用钙通道阻滞剂和较高水平的HbA1c的存在进一步与严重的ED相关。与没有ED的患者相比，患有严重ED的男性的睾丸激素水平低于正常人群。高灵敏度的C反应蛋白水平和代谢综合征的存在不是危险因素。与ED患者相比，问卷的211名无应答者具有相似或较差的风险特征。结论。调整年龄和糖尿病持续时间后，白蛋白尿是糖尿病男性ED的重要独立危险因素。识别和控制蛋白尿及其他相关危险因素可能在ED的预防或逆转中起作用。

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