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首页> 外文期刊>The journal of sexual medicine >A new female rat animal model for hypoactive sexual desire disorder; behavioral and pharmacological evidence.
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A new female rat animal model for hypoactive sexual desire disorder; behavioral and pharmacological evidence.

机译：一种新的雌性大鼠性欲减退动物模型;行为和药理证据。

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INTRODUCTION: Female sexual dysfunction (FSD) affects 33-48% of women. Female rats with low sexual activity might model FSD. AIM: In this study, we have investigated whether in a population of normal female rats, subpopulations of rats exist with different levels of sexual behavior. METHODS: Sexually experienced, intact, estradiol-primed female rats were placed in an empty compartment adjacent to a compartment with a male. The females were allowed, during 30 minutes, to switch between the compartments via a hole through which only the females could pass (paced mating). Next, we investigated the acute effects on female sexual behavior of apomorphine, a D(1) - and D(2) -type dopamine receptor agonist, (+/-)-8-hydroxy-2-(dipropylamino)tetralin hydrobromide (+/- 8-OH-DPAT), a 5-HT1A receptor agonist, and paroxetine, a selective serotonin reuptake inhibitor. MAIN OUTCOME MEASURES: Time spent in compartments, proceptive behaviors, contact-return latencies, and percentages of exits were quantified. RESULTS: Based on their behavior in the paced mating sex test, estradiol-primed, intact female rats can be divided into three groups: those that mostly avoid the male, a large middle group, and those that mostly approach the male. The avoiders also showed significantly less proceptive behavior than the male approachers. The sexual behavior of the females was relatively stable over time, suggesting the existence of different endophenotypes in female rats. Apomorphine and +/- 8-OH-DPAT had an inhibiting effect on sexual behavior, but only females dosed with apomorphine showed a different response in avoiders and approachers, more inhibiting effect in avoiders than approachers. Paroxetine had no effect on proceptive behavior. DISCUSSION: The stable, male-avoiding behavior of some females might correspond to the characteristics of women with FSD. Therefore, these avoiders are a promising new model for FSD, specifically for sexual desire and/or arousal disorders. Furthermore, the apomorphine data suggest that differences in the dopamine system may (partly) underlie the differences in sexual behaviors between avoiders and approachers.
机译：简介：女性性功能障碍（FSD）会影响33-48％的女性。性活动低的雌性大鼠可能会模拟FSD。目的：在这项研究中，我们调查了正常雌性大鼠种群中是否存在具有不同水平性行为的大鼠亚群。方法：将有性经验的，完整的雌二醇引发的雌性大鼠放在与雄性隔室相邻的空隔室中。在30分钟内，允许雌性通过一个只有雌性可以通过的孔（定步交配）在隔间之间切换。接下来，我们研究了Apomorphine，D（1）和D（2）型多巴胺受体激动剂（+/-）-8-羟基-2-（dipropylamino）tetralin hydrobromide（+）对女性性行为的急性影响/-8-OH-DPAT）（一种5-HT1A受体激动剂）和帕罗西汀（一种选择性的5-羟色胺再摄取抑制剂）。主要观察指标：量化在车厢内所花费的时间，感觉行为，接触-返回潜伏期和离开百分比。结果：根据雌性雌二醇引发的完整雌性大鼠在节律性交配性试验中的行为，可分为三组：大多数避免雄性的大鼠，较大的中型组和大多数接近雄性的大鼠。与男性接近者相比，回避者的性行为也明显更少。雌性的性行为随着时间的推移相对稳定，表明雌性大鼠中存在不同的内表型。阿扑吗啡和+/- 8-OH-DPAT对性行为有抑制作用，但只有雌性阿扑吗啡给药的女性在回避者和接近者中表现出不同的反应，在回避者中的抑制作用比接近者更大。帕罗西汀对感觉行为没有影响。讨论：某些女性的稳定，避免男性行为可能与FSD女性的特征相对应。因此，这些回避者是有前途的FSD新模式，特别是对于性欲和/或性唤起障碍。此外，阿扑吗啡的数据表明，多巴胺系统的差异可能（部分）是回避者和进场者之间性行为差异的基础。

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