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首页> 外文期刊>The journal of sexual medicine >Role of the neurokinin-1 receptors in ejaculation in anesthetized rats.
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Role of the neurokinin-1 receptors in ejaculation in anesthetized rats.

机译：神经激肽-1受体在麻醉大鼠射精中的作用。

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INTRODUCTION: Several lines of evidence indicate a role for substance P in the control of ejaculation, although its mode of action needs to be clarified. AIM: The effects and sites of action of a selective antagonist for the substance P-preferred receptor (neurokinin-1 receptor subtype; NK1) were investigated in a pharmacological model of ejaculation. METHODS: Ejaculation was induced in anesthetized rats by intracerebroventricular (i.c.v.) delivery of the dopamine D3 receptor preferring agonist 7-hydroxy-2-(di-N-propylamino)tetralin (7-OH-DPAT). The effects of the selective NK1 antagonist RP67580 on 7-OH-DPAT-induced ejaculation were measured following intraperitoneal (i.p.), i.c.v., or intrathecal (i.t.) (third lumbar spinal segment; L3) administration. MAIN OUTCOME MEASURES: Intraseminal vesicle pressure (SVP) and electromyogram of the bulbospongiosus muscle (BS) were recorded as physiological markers of emission and expulsion phases of ejaculation, respectively. RESULTS: Upon i.p., i.c.v., or i.t. administration, RP67580 significantly reduced the occurrence of ejaculation elicited by 7-OH-DPAT. A mild decrease in the occurrence of SVP and BS responses was observed in rats treated ip with RP67580, whereas only SVP responses were moderately affected following i.c.v. or i.t. administration. CONCLUSION: These results show the multilevel regulation of 7-OH-DPAT-induced ejaculation by NK1 receptors.
机译：引言：尽管需要阐明其作用方式，但有几条证据表明P物质在控制射精中的作用。目的：在射精的药理模型中研究了针对P偏好受体（神经激肽1受体亚型; NK1）的选择性拮抗剂的作用和作用部位。方法：通过脑室内（i.c.v.）释放多巴胺D3受体（优选激动剂7-羟基-2-（二-N-丙基氨基）四氢化萘（7-OH-DPAT））诱导麻醉的大鼠射精。在腹膜内（i.p.），静脉内或鞘内（i.t.）（第三腰椎节段; L3）给药后，测量选择性NK1拮抗剂RP67580对7-OH-DPAT诱导的射精的影响。主要观察指标：记录射精期囊泡内压力（SVP）和球囊肌肉（BS）的肌电图分别作为射精发射阶段和排出阶段的生理指标。结果：在i.p.，i.c.v。或i.t.给药后，RP67580显着减少了7-OH-DPAT引起的射精的发生。在腹腔注射RP67580的大鼠中观察到SVP和BS反应的发生程度有轻度降低，而在静脉内注射后仅SVP反应受到中等程度的影响。或行政。结论：这些结果表明NK1受体对7-OH-DPAT诱导的射精有多级调节。

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