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首页> 外文期刊>The journal of sexual medicine >Anencephaly does not cause structural alterations in the fetal penis
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Anencephaly does not cause structural alterations in the fetal penis

机译：无脑畸形不会引起胎儿阴茎结构改变

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Introduction. Anencephaly is the most severe neural tube defect in human fetuses. There is an increasing need for tissue replacement in chronic diseases and reconstructive surgeries. Fetal tissues have been used as a substitute for native organs. Aim. The aim of this article was to compare the structure and morphology of the corpora cavernosa (CC) and spongiosum (SP) of penises from anencephalic and normal human fetuses. Main Outcome Measures. The main outcome measures of this study were the proposition of a new model for biological studies and tissue transplantation. Methods. We studied 11 penises from normal human fetuses, aged 14-23 weeks postconception (WPC), and five penises from anencephalic fetuses, aged 18-22 WPC. The organs were removed and processed by routine histological and immunolabeling techniques. Analysis of connective tissue (Cot), smooth muscle (SMC), and elastic fiber (EF) were performed in sections. Data were expressed as area density (Ad) using digital processing and software. Means were statistically compared using the unpaired t-test and linear regression was performed. Statistical significance was considered if P0.05. Results. The intracavernosal septum was present in all samples. We did not observe differences in the Ad of Cot and SMC in the penises of anencephalic fetuses when compared with normal ones. The simple linear regression suggested that during human development, there is a gradual increase in Cot (R 2=+0.45) and a decrease of SMC (R 2=-0.62) in the CC in both groups studied. Elastin was observed only in fetuses from 20th WPC. Conclusions. There was no difference in the structure of the CC and corpus SP of anencephalic fetuses compared with normal ones. Elastin was documented from 20th WPC, which suggests the maintenance of erectile function. Histochemistry and immunolabeling suggested that penile shaft development is maintained and unaltered in anencephalic fetuses. Further studies should be performed to analyze anencephalic fetuses as a potential tissue-donating group and a model for biological studies.
机译：介绍。无脑是人类胎儿中最严重的神经管缺陷。在慢性疾病和重建手术中，越来越需要组织替代。胎儿组织已被用作天然器官的替代物。目标。本文旨在比较无脑和正常人类胎儿阴茎海绵体（CC）和海绵体（SP）的结构和形态。主要观察指标。这项研究的主要结果指标是提出一种新的生物学研究和组织移植模型。方法。我们研究了11名来自正常人胎儿的阴茎，其年龄在受孕后14-23周（WPC），以及五只来自无脑胎儿的阴茎，年龄分别为18-22 WPC。通过常规的组织学和免疫标记技术去除器官并进行处理。进行结缔组织（Cot），平滑肌（SMC）和弹性纤维（EF）的分析。使用数字处理和软件将数据表示为面积密度（Ad）。使用不配对t检验对平均值进行统计学比较，并进行线性回归。如果P ＜0.05，则考虑统计学显着性。结果。所有样品中均存在海绵体间隔。我们没有观察到与正常人相比，无脑胎儿的阴茎中Cot和SMC的Ad差异。简单的线性回归表明，在研究的两组中，CC中Cot逐渐升高（R 2 = + 0.45），SMC降低（R 2 = -0.62）。弹性蛋白仅在第20届WPC的胎儿中观察到。结论。与正常人相比，无脑胎儿的CC和SP体结构没有差异。弹性蛋白从第20届WPC记录下来，表明维持勃起功能。组织化学和免疫标记表明，脑性胎儿中阴茎干的发育得以维持且未改变。应该进行进一步的研究以分析脑胎儿作为潜在的组织捐赠者和生物学研究的模型。

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