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首页> 外文期刊>The journal of sexual medicine >Ejaculation profiles of men following radiation therapy for prostate cancer
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Ejaculation profiles of men following radiation therapy for prostate cancer

机译：前列腺癌放射治疗后男性的射精曲线

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Objectives: Radical prostatectomy (RP) is associated with anejaculation, which for some men is a source of bother and sexual dissatisfaction. Clinical experience has shown us some men after pelvic radiation therapy (RT) also experience anejaculation. This analysis was conducted to define the ejaculation profiles of men after RT for prostate cancer (PCa). Methods: As a routine part of the sexual health evaluation for post-RT patients, men provided information regarding their ejaculatory function and orgasm. Analysis was conducted of a sexual medicine database reviewing demographic data, PCa factors, erectile, ejaculatory, and orgasmic function. Men with prior history of RP, cryotherapy, focal therapies, and androgen deprivation therapy (ADT) were excluded. Patients completed the International Index of Erectile Function (IIEF) questionnaire at follow-up visits commencing with the first posttreatment visit and specific attention was paid to the IIEF orgasm domain. Results: Three hundred and sixty-four consecutive patients were included. Two hundred and fifty-two patients had external beam, and 112 patients had brachytherapy (BT). Mean age was 64±11 (42-78) years and mean follow-up after RT was 6±4.5 years. Mean prostate size at time of RT was 42±21g. Of the entire population, 72% lost the ability to ejaculate in an antegrade fashion after prostate RT by their last visit. The proportion experiencing anejaculation at 1, 3, and 5 years after RT was 16%, 69%, and 89%, respectively. For men with at least two IIEF questionnaires completed, the orgasm domain scores decreased dramatically over the follow-up period; orgasm domain scores (0-10): <12 months post-RT 7.4, 13-24 months 5.4, 25-36 months 3.2, >36 months 2.8 (P<0.01). Multivariable analysis identified several factors predictive of failure to ejaculate: older age, ADT, RT dose>100Gy, and smaller prostates at the time of RT. Conclusions: The vast majority of men after prostate RT will experience anejaculation and should be counseled accordingly prior to undergoing therapy. We have identified predictive factors.
机译：目的：根治性前列腺切除术（RP）与射精有关，对于某些男性来说，这是引起性不满和性不满的原因。临床经验表明，一些接受盆腔放射疗法（RT）的男性也有射精的经历。进行该分析以定义男性在接受RT治疗后前列腺癌（PCa）的射精情况。方法：作为RT后患者性健康评估的常规部分，男性提供了有关其射精功能和性高潮的信息。对性医学数据库进行了分析，回顾了人口统计学数据，PCa因子，勃起，射精和性高潮功能。曾有RP，冷冻疗法，局部疗法和雄激素剥夺疗法（ADT）病史的男性被排除在外。从首次治疗后访视开始，患者在随访中完成了国际勃起功能指数（IIEF）问卷调查，并特别注意了IIEF性高潮领域。结果：纳入364例连续患者。 252例患者有外束，112例患者进行了近距离放射治疗（BT）。平均年龄为64±11（42-78）岁，放疗后的平均随访时间为6±4.5岁。 RT时的平均前列腺大小为42±21g。在整个人群中，有72％的人在最后一次造访前列腺癌后丧失了顺行射精的能力。放疗后1、3和5年发生射精的比例分别为16％，69％和89％。对于完成至少两份IIEF问卷的男性，性高潮领域评分在随访期内显着下降;性高潮领域评分（0-10）：放疗后<12个月7.4、13-24个月5.4、25-36个月3.2，> 36个月2.8（P <0.01）。多变量分析确定了几种预测射精失败的因素：年龄较大，ADT，RT剂量> 100Gy和RT时前列腺较小。结论：绝大多数接受前列腺放疗的男性会经历射精，因此在接受治疗之前应进行相应的咨询。我们已经确定了预测因素。

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