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首页> 外文期刊>The journal of sexual medicine >Flibanserin treatment increases appetitive sexual motivation in the female rat
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Flibanserin treatment increases appetitive sexual motivation in the female rat

机译：氟班色林治疗可增加雌性大鼠的食欲性动机

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Introduction.: Flibanserin is a mixed 5-HT1A agonist/5-HT2A antagonist that has been developed for the treatment of hypoactive sexual desire disorder in women. Aim.: To assess the acute and chronic dose-response effects of flibanserin on measures of sexual desire and copulation in ovariectomized rats primed with estradiol benzoate (EB) alone or in combination with progesterone (P). Methods.: In Experiment 1, sexually experienced ovariectomized (OVX) rats at one testing site were rendered fully sexually receptive with EB+P priming and tested weekly with a sexually active male in bi-level pacing chambers following daily flibanserin treatment for 28 days. In Experiment 2, sexually experienced OVX rats at a different testing site received EB alone and were tested weekly with sexually active males following daily flibanserin treatment. Main Outcome Measures.: Female appetitive behaviors (solicitations, hops and darts, anogenital investigations), defensive behaviors, pacing, lordosis, and male copulatory responses (intromissions and ejaculations) were measured during each 30-minute copulation test. Results.: Acute flibanserin or 1 week of chronic flibanserin treatment did not modify sexual responses in fully (EB+P) or partially (EB-alone) primed females. After 2 weeks of chronic treatment, fully primed females displayed significantly more solicitations than the three other groups. After 3 weeks of chronic treatment, a significant increase in female solicitations was observed in both hormone-treatment groups. Conclusion.: This study shows the first evidence that chronic, but not acute, flibanserin treatment augments appetitive sexual behaviors in OVX female rats primed with EB+P or EB alone. Given the positive effect of flibanserin in clinical trials, these results confirm previous reports that solicitations in the female rat are a predictive animal model of human female sexual desire.
机译：简介：氟班色林是一种5-HT1A激动剂/ 5-HT2A混合拮抗剂，已被开发用于治疗女性性欲减退症。目的：评估氟班色林对单独或联合雌二醇苯甲酸酯（EB）或与孕酮（P）灌注的去卵巢大鼠性欲和交配的急性和慢性剂量反应作用。方法：在实验1中，在一个测试部位将有性行为的卵巢切除（OVX）大鼠完全接受EB + P引发的性感受，并在每天接受氟班色林治疗28天后，每周两次在两级起搏室内对有性活跃的雄性进行测试。在实验2中，有性行为的OVX大鼠在不同的测试点接受了单独的EB，并在每天接受氟班色林治疗后每周进行一次性活跃的雄性动物的测试。主要结果指标：在每30分钟的交配测试中，测量女性的食欲行为（招揽，蛇麻草和飞镖，生殖器检查），防御行为，起搏，前凸和男性交配反应（引射和射精）。结果：急性氟班色林或1周慢性氟班色林治疗未改变完全（EB + P）或部分（仅EB单独）初治女性的性反应。经过2周的长期治疗，与其他三个组相比，完全准备好的女性表现出明显更多的诱因。长期治疗3周后，两个荷尔蒙治疗组中的女性诱因均显着增加。结论：这项研究显示了第一个证据，即长期但非急性的氟班色林治疗可增强仅用EB + P或EB引发的OVX雌性大鼠的食欲性行为。考虑到氟班色林在临床试验中的积极作用，这些结果证实了以前的报道，即在雌性大鼠中进行诱骗是人类女性性欲的预测动物模型。

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