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首页> 外文期刊>The journal of sexual medicine >Increasing the Dose of Vardenafil on a Daily Basis Does Not Improve Erectile Function after Unilateral Nerve-Sparing Radical Prostatectomy
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Increasing the Dose of Vardenafil on a Daily Basis Does Not Improve Erectile Function after Unilateral Nerve-Sparing Radical Prostatectomy

机译：每天增加伐地那非的剂量并不能改善单侧保留神经根治性前列腺切除术后的勃起功能

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Introduction. Several treatment regimens for rehabilitation of erectile function (EF) after nerve-sparing radical prostatectomy (nsRP) are currently discussed. The optimal and most cost-effective therapy is still not found yet. Aim. To evaluate the effect of vardenafil, a PDE5 inhibitor, dose escalation on recovery of EF after unilateral nsRP. Methods. Thirty-six sexually active patients received a unilateral nsRP. All patients completed an International Index of Erectile Function-5 items (IIEF-5) questionnaire concerning EF preoperatively. Group 1 (N=12 patients) received vardenafil 5mg/day vs. group 2 (N=12) who received vardenafil 10mg/day at night beginning the day of catheter removal. A control of 12 patients underwent follow-up without PDE5 inhibitors. Main Outcome Measure. The IIEF-5 was the primary end point. IIEF-5 questionnaires were completed at baseline, 3, 6, and 12 months after nsRP. Results. In group 1 (5mg/day vardenafil) the IIEF-5 score decreased from a preoperative 22.4 mean score to 4.2 at 3 months, 8.9 at 6 months, and 13.4 mean score at 12 months after nsRP vs. preoperative 22.8, 4.1 at 3 months, 7.9 at 6 months, and 12.8 mean score at 12 months in group 2 (10mg/day vardenafil). In the control group the preoperative IIEF-5 mean score of 21.9 decreased to 3.8 at 3 months, 6.1 at 6 months, and 8.9 at 12 months. Statistical evaluation showed significant difference in IIEF-5 score and time to recovery of EF between groups 1 and 3 and between groups 2 and 3 (P<0.01). No statistical differences were found between groups 1 and 2. Conclusions. Daily low-dose vardenafil lead to significant improvement of recovery of EF. In this study doubling the dosage did not improve the recovery of EF further.
机译：介绍。目前讨论了保留神经的根治性前列腺切除术（nsRP）后恢复勃起功能（EF）的几种治疗方案。最佳和最具成本效益的治疗方法尚未找到。目标。为了评估伐地那非（一种PDE5抑制剂）的剂量递增对单侧nsRP后EF恢复的影响。方法。 36名性活跃患者接受了单侧nsRP。所有患者术前均完成了一项有关EF的国际勃起功能指数5（IIEF-5）问卷。第1组（N = 12例患者）接受伐地那非5mg /天，而第2组（N = 12）接受伐地那非10mg /天，在拔除导管之夜开始。对照的12例患者接受了无PDE5抑制剂的随访。主要结果指标。 IIEF-5是主要终点。 IIEF-5问卷在nsRP后的基线，3、6和12个月完成。结果。在第1组（5mg /天的伐地那​​非）中，IIEF-5评分从术前的22.4分降至nsRP后的3个月为4.2，6个月的为8.9，以及12个月时的13.4的均分，而术前为22.8、4.1个月的3分，第2组（10毫克/天伐地那非）在6个月时为7.9，在12个月时平均得分为12.8。在对照组中，术前IIEF-5的平均评分为21.9，在3个月时降至3.8，在6个月时降至6.1，在12个月时降至8.9。统计评估显示，第1组和第3组之间以及第2组和第3组之间IIEF-5评分和EF恢复时间有显着差异（P <0.01）。第1组和第2组之间未发现统计学差异。每日小剂量伐地那非可导致EF恢复明显改善。在这项研究中，加倍剂量并不能进一步提高EF的回收率。

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