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首页> 外文期刊>The journal of sexual medicine >Association between neuropathic pain, pregabalin treatment, and erectile dysfunction
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Association between neuropathic pain, pregabalin treatment, and erectile dysfunction

机译：神经性疼痛，普瑞巴林治疗与勃起功能障碍之间的关联

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Introduction: The pathophysiology of erectile dysfunction (ED) may be vasculogenic, hormonal, anatomical, neurogenic, drug-induced and/or psychogenic in origin. Neuropathic pain (NP) may facilitate ED, because it is frequently associated with anxiety, depression, and its drug, pregabalin, may also contribute ED. Aim: The objective of this study was to determine whether pregabalin treatment for patients with neuropathic pain promotes erectile dysfunction. Methods: The study sample consisted of a total of 102 male subjects that were subdivided into three groups. Group 1 patients (n=31) had a pre-existing diagnosis of NP and was treated with 300mg/day of pregabalin for at least 3 months. Group 2 patients (n=34) were diagnosed with NP for at least 3 months; however, neither were they treated with pregabalin nor did they received physical therapy throughout the study. Lastly, healthy age-matched control subjects comprised group 3 (n=37). Main Outcome Measures: Patients in all groups completed the International Index for Erectile Function (IIEF) questionnaire. Results: Mean age and mean body mass index did not differ significantly between each of the three groups. The cause of NP and the mean duration of having a diagnosis of NP did not differ significantly in groups 1 and 2. However, IIEF scores were significantly lower for group 1 when compared to group 2 in terms of erectile function, orgasmic function, overall satisfaction and total score. Yet groups 1 and 2 did not diverge significantly in the intercourse satisfaction and sexual desire scores. Overall IIEF scores for group 3 were significantly higher than those of group 2 except for mean erectile function scores. Conclusion: Taking pregabalin for the treatment of neuropathic pain poses an increased risk for developing ED in male patients. Thus, clinicians prescribing pregabalin to patients diagnosed with neuropathic pain should assess for ED before and during treatment with this medication.
机译：简介：勃起功能障碍（ED）的病理生理学可能起源于血管生成，激素生成，解剖学生成，神经生成，药物诱导生成和/或精神生成。神经性疼痛（NP）可能会促进ED，因为它经常与焦虑，抑郁相关，并且其药物普瑞巴林也可能导致ED。目的：本研究的目的是确定普瑞巴林治疗神经性疼痛患者是否会促进勃起功能障碍。方法：研究样本由总共102名男性受试者组成，分为三组。第1组患者（n = 31）已有NP诊断，并接受300mg /天的普瑞巴林治疗至少3个月。第2组患者（n = 34）被诊断患有NP至少3个月;然而，在整个研究过程中，既未接受普瑞巴林治疗，也未接受物理治疗。最后，年龄匹配的健康对照者包括第3组（n = 37）。主要指标：所有组的患者均完成了国际勃起功能指数（IIEF）问卷调查。结果：三组之间的平均年龄和平均体重指数没有显着差异。在第1组和第2组中，NP的原因和诊断为NP的平均持续时间无明显差异。但是，与勃起功能，性高潮功能，总体满意度相比，第1组的IIEF得分明显低于第2组和总分。但是，第1组和第2组的性交满意度和性欲得分没有明显差异。除平均勃起功能评分外，第3组的IIEF总体得分明显高于第2组。结论：服用普瑞巴林治疗神经性疼痛会增加男性患者发生ED的风险。因此，对诊断为神经性疼痛的患者开处方普瑞巴林的临床医生应在用这种药物治疗之前和期间评估ED。

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