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首页> 外文期刊>The journal of sexual medicine >Testosterone Supplementation and Sexual Function: A Meta-Analysis Study
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Testosterone Supplementation and Sexual Function: A Meta-Analysis Study

机译：补充睾丸激素和性功能：一项荟萃分析研究

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Introduction The role of testosterone supplementation (TS) as a treatment for male sexual dysfunction remains questionable. Aim The aim of this study was to attempt a meta-analysis on the effect of TS on male sexual function and its synergism with the use of phosphodiesterase type 5 inhibitor (PDE5i). Methods An extensive Medline, Embase, and Cochrane search was performed. Main Outcome Measures All randomized controlled trials (RCTs) comparing the effect of TS vs. placebo or the effect of TS as add on to PDE5is on sexual function were included. Data extraction was performed independently by two of the authors (A. M. Isidori and G. Corona), and conflicts resolved by the third investigator (M. Maggi). Results Out of 1,702 retrieved articles, 41 were included in the study. In particular, 29 compared TS vs. placebo, whereas 12 trials evaluated the effect of TS as add on to PDE5is. TS is able to significantly ameliorate erectile function and to improve other aspects of male sexual response in hypogonadal patients. However, the presence of possible publication bias was detected. After applying trim and fill method, the positive effect of TS on erectile function and libido components retained significance only in RCTs partially or completely supported by pharmaceutical companies (confidence interval [0.04-0.53] and [0.12; 0.52], respectively). In addition, we also report that TS could be associated with an improvement in PDE5i outcome. These results were not confirmed in placebo-controlled studies. The majority of studies, however, included mixed eugonadal/hypogonadal subjects, thus imparting uncertainty to the statistical analyses. Conclusions TS plays positive effects on male sexual function in hypogonadal subjects. The role of TS is uncertain in men who are not clearly hypogonadal. The apparent difference between industry-supported and independent studies could depend on trial design more than on publication bias. New RCTs exploring the effect of TS in selected cases of PDE5i failure that persistently retain low testosterone levels are advisable. Corona G, Isidori AM, Buvat J, Aversa A, Rastrelli G, Hackett G, Rochira V, Sforza A, Lenzi A, Mannucci E., and Maggi M. Testosterone supplementation and sexual function: A meta-analysis study. J Sex Med 2014;11:1577-1592.
机译：简介补充睾丸激素（TS）作为治疗男性性功能障碍的作用仍然值得怀疑。目的本研究的目的是尝试通过使用5型磷酸二酯酶（PDE5i）对TS对男性性功能及其协同作用的影响进行荟萃分析。方法进行了广泛的Medline，Embase和Cochrane搜索。主要结果指标包括所有比较TS与安慰剂或PDE5上添加TS对性功能影响的随机对照试验（RCT）。数据提取是由两位作者（A. M. Isidori和G. Corona）独立进行的，而冲突由第三位研究者（M. Maggi）解决。结果在1,702篇检索文章中，有41篇被纳入研究。特别是，有29例将TS与安慰剂进行了比较，而12项试验评估了TS对PDE5is的影响。 TS能显着改善性腺功能减退患者的勃起功能并改善男性性反应的其他方面。但是，检测到可能的发布偏差。在应用修剪和填充方法后，TS对勃起功能和性欲成分的积极影响仅在部分或完全由制药公司支持的RCT中保持显着性（置信区间[0.04-0.53]和[0.12; 0.52]）。此外，我们还报告说TS可能与PDE5i结局的改善有关。这些结果在安慰剂对照研究中未得到证实。然而，大多数研究包括混合性腺癌/性腺功能减退的受试者，因此给统计分析带来了不确定性。结论TS对性腺功能减退者的男性性功能有积极影响。对于不清楚性腺功能减退的男性，TS的作用尚不确定。行业支持的研究与独立研究之间的明显差异可能取决于试验设计，而不是取决于出版物的偏倚。建议使用新的RCT，探讨在选定的PDE5i失败病例中持续保留低睾丸激素水平的TS的影响。 Corona G，Isidori AM，Buvat J，Aversa A，Rastrelli G，Hackett G，Rochira V，Sforza A，Lenzi A，Mannucci E.和Maggi M.睾丸激素补充和性功能：一项荟萃分析研究。 J Sex Med 2014; 11：1577-1592。

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