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首页> 外文期刊>The journal of sexual medicine >Short- and Long-Term Clinical Skin Effects of Testosterone Treatment in Trans Men
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Short- and Long-Term Clinical Skin Effects of Testosterone Treatment in Trans Men

机译：跨性别男性睾丸激素治疗的短期和长期临床皮肤影响

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Introduction: Our knowledge concerning the effects of testosterone (T) therapy on the skin of trans men (female-to-male transsexuals) is scarce. Aim: The aim of this study was to evaluate the short- and long-term clinical effects of T treatment on the skin of trans men. Methods: We conducted a prospective intervention study in 20 hormone naive trans men and a cross-sectional study in 50 trans men with an average of 10 years on T therapy. Main Outcome Measures: Acne lesions were assessed using the Gradual Acne Grading Scale, hair patterns using the Ferriman and Gallwey classification (F&G), and androgenetic alopecia using the Norwood Hamilton Scale. Results: T treatment increased facial and body hair growth. The F&G score increased progressively from a median value of 0.5 at baseline to a value of 12 after 12 months of T administration. After long-term T treatment, all but one trans man achieved an F&G score indicative of hirsutism in women, with a median value of 24. Only one trans man acquired mild frontotemporal hair loss during the first year of T treatment, whereas 32.7% of trans men had mild frontotemporal hair loss and 31% had moderate to severe androgenetic alopecia after long-term T therapy. The presence and severity of acne increased during the first year of T therapy, and peaked at 6 months. After long-term T treatment, most participants had no or mild acne lesions (93.9%). Dermatological outcome was not demonstrably related to individual serum T or dihydrotestosterone levels. Conclusions: T treatment increased facial and body hair in a time-dependent manner. The prevalence and severity of acne in the majority of trans men peaked 6 months after beginning T therapy. Severe skin problems were absent after short- and long-term T treatment.
机译：简介：我们对睾丸激素（T）治疗对跨性别者（男性至男性变性者）皮肤的影响的了解很少。目的：本研究的目的是评估T治疗对跨性别男人皮肤的短期和长期临床效果。方法：我们对20位激素初次接受治疗的跨性别男人进行了一项前瞻性干预研究，并对50位平均接受T治疗10年的跨性别男人进行了横断面研究。主要结局指标：使用渐进痤疮分级量表评估痤疮病变，使用Ferriman和Gallwey分类（F＆G）评估头发类型，并使用Norwood Hamilton量表评估雄激素性脱发。结果：T治疗可增加面部和身体毛发生长。 F＆G评分从基线的中位数0.5逐渐增加到T给药12个月后的12。经过长期的T治疗后，除一名跨性别男人外，所有其他跨性别者均获得F＆G评分，表明女性多毛症，中位值为24。只有一名跨性别男人在T治疗的第一年出现额颞叶轻度脱发，而其中32.7％在长期T治疗后，跨性别者轻度额颞脱发，31％患有中度至重度雄​​激素性脱发。在T治疗的第一年，痤疮的出现和严重程度增加，并在6个月达到高峰。经过长期的T治疗后，大多数参与者没有或有轻度痤疮病变（93.9％）。皮肤病学结局与个体血清T或二氢睾丸激素水平无明显关系。结论：T治疗以时间依赖性方式增加面部和体毛。在大多数T型男性中，痤疮的患病率和严重程度在开始T治疗后6个月达到峰值。短期和长期的T治疗后，没有出现严重的皮肤问题。

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